HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: WIPI2 (Q9Y4P8)
WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)
Gene: WIPI2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30340022, 25147182
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 4374 Hs			1 454
+	Hs
		1192155 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		FBXW7_HUMAN (140-429): 1.13e-45: 170: 9.12
+	Hs
		929534 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		RACK1_HUMAN (177-426): 2.51e-14: 75.6: 16.54
+	Hs
		125355 WWP2_HUMAN (3506-4372): 0: 624: 24.57		RACK1_HUMAN (177-426): 2.51e-14: 75.6: 16.54
+	Hs
		929669 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		RACK1_HUMAN (177-426): 2.51e-14: 75.6: 16.54
+	Hs
		125310 WWP2_HUMAN (3506-4372): 0: 624: 24.57		WDR5_HUMAN (319-430): 3.33e-10: 63: 12.80
+	Hs
		125699 WWP2_HUMAN (3506-4372): 0: 624: 24.57		SKI8_HUMAN (22-233): 3.35e-10: 62.9: 13.83
+	Sc
		635632 TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77		PWP2_YEAST (14-359): 1.47e-22: 102: 16.53
+	Dm
		113992 M9PB30_DROME (1419-2196): 1.16e-10: 70.7: 7.71		Q9VSF0_DROME (38-376): 4.78e-80: 254: 60.52
+	Dm
		113977 M9PB30_DROME (1419-2196): 1.16e-10: 70.7: 7.71		GBLP_DROME (151-379): 1.22e-12: 70.6: 16.39