HitPredict

Interactor 1: RING2 (Q803I4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: rnf2

Interactor 2: BMI1A (Q8JIR0)
Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A)
Gene: BMI1A

Species: Danio rerio

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21195142
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 336 Dr			1 320
+	Mm
		639478 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		BMI1_MOUSE (1-319): 6.62e-101: 301: 81.06
+	Hs
		718129 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		BMI1_HUMAN (1-320): 4.19e-101: 301: 79.45
+	Hs
		718420 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		PCGF2_HUMAN (1-315): 1.19e-99: 298: 60.36
+	Mm
		620793 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		PCGF2_MOUSE (1-315): 2.37e-95: 287: 60.06
+	Dr
		1186371 RING2_DANRE (1-336): 3.15e-105: 313: 100.00		BMI1B_DANRE (1-317): 4.7e-91: 276: 74.92
+	Mm
		1207257 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		PCGF3_MOUSE (4-226): 1.22e-61: 197: 32.34
+	Hs
		1108533 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		PCGF3_HUMAN (4-226): 1.71e-61: 197: 33.05
+	Hs
		1019359 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		TRI26_HUMAN (5-307): 1.04e-54: 188: 15.24
+	Hs
		1304081 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		PCGF6_HUMAN (2-233): 1.39e-55: 185: 36.67
+	Mm
		1246747 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		PCGF1_MOUSE (2-227): 7.57e-56: 183: 35.75
+	Hs
		1304074 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		PCGF1_HUMAN (2-227): 1.34e-55: 183: 35.32
+	Mm
		1321732 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		RING2_MOUSE (7-230): 4.32e-54: 181: 17.67
+	Hs
		1304059 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		RING2_HUMAN (7-230): 6.08e-54: 181: 17.67
+	Mm
		1307909 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		PCGF6_MOUSE (2-233): 4.22e-53: 179: 36.25
+	Mm
		1112809 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		PCGF5_MOUSE (1-219): 4.55e-49: 166: 29.52
+	Hs
		537009 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		TRI27_HUMAN (10-286): 2.12e-46: 165: 14.13
+	Hs
		1197582 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		PCGF5_HUMAN (1-220): 2.81e-47: 161: 28.51
+	Mm
		193415 RING2_MOUSE (1-336): 9.15e-107: 317: 89.29		RING1_MOUSE (7-132): 1.11e-31: 124: 23.44
+	Hs
		988012 RING2_HUMAN (1-336): 2.52e-106: 316: 89.29		RING1_HUMAN (7-132): 5.32e-31: 122: 24.22
+	Mm
		193402 RING1_MOUSE (8-336): 1.37e-70: 226: 51.49		RING1_MOUSE (7-132): 1.11e-31: 124: 23.44