Protein: 6PGD
6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)

Gene: 6PGD, PGD
Organism: Homo sapiens
Interactions: 109
UniProt ID: P52209

Gene Ontology (top 5):
GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006098 - pentose-phosphate shunt
GO:0009051 - pentose-phosphate shunt, oxidative branch

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

241153

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

425389

ISG15
Ubiquitin-like protein ISG15

2

4

High-throughput

0.584

High

910330

ACE2
Angiotensin-converting enzyme 2

2

1

High-throughput

0.584

High

176950

CE290
Centrosomal protein of 290 kDa

2

1

High-throughput

0.571

High

371522

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.571

High

635696

RASA1
Ras GTPase-activating protein 1

2

1

High-throughput

0.571

High

869282

XDH
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

2

0

High-throughput

0.559

High

289963

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

529386

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

783539

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

908897

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

910309

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

910323

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

910336

PAK6
Serine/threonine-protein kinase PAK 6

1

1

High-throughput

0.536

High

910343

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.536

High

910281

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

774225

BASI
Basigin

1

2

High-throughput

0.515

High

213868

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

910298

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

910308

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

910321

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

0

High-throughput

0.513

High

910331

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

185542

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

910286

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

910319

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.489

High

344522

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.486

High

549101

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.481

High

136853

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

487115

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

588257

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

667668

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

694983

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

722689

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.479

High

789449

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.479

High

798874

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

851728

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

872097

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

910287

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

910289

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

910291

H4
Histone H4

1

1

High-throughput

0.479

High

910292

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

910294

CAP1
Adenylyl cyclase-associated protein 1

1

1

High-throughput

0.479

High

910299

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

910300

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

910301

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

910302

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

910303

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

910306

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

910310

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

910315

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

910322

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

910325

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

910326

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

910328

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

910329

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

910335

DUS21
Dual specificity protein phosphatase 21

1

1

High-throughput

0.479

High

910337

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

910340

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

910341

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

910342

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

258811

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

259659

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

289471

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.458

High

379956

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

420439

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

457323

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

536795

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

606468

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

630733

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.458

High

643738

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

830384

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

868986

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

910285

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

910290

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

910293

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

910304

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

910316

CDC73
Parafibromin

1

0

High-throughput

0.458

High

910324

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

910338

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

910339

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

711855

LTK
Leukocyte tyrosine kinase receptor

1

1

High-throughput

0.457

High

765277

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

910282

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

910284

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

910312

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

910314

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

910296

GLGB
1,4-alpha-glucan-branching enzyme

1

0

High-throughput

0.438

High

105613

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

318673

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.437

High

767751

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

910311

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

910317

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

910327

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.437

High

910333

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

910334

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

563456

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

838028

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

910283

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

910288

SMS
Somatostatin

1

0

Small-scale

0.426

High

910305

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

910318

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

910313

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.279

Low

353126

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

910295

CAV1
Caveolin-1

1

0

High-throughput

0.249

Low

910307

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

554187

BMP4
Bone morphogenetic protein 4

1

0

High-throughput

0.232

Low

910297

P
P protein

1

0

High-throughput

0.232

Low

910320

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

910332

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025