HitPredict

Interactor 1: AP2S (Q84WL9)
AP-2 complex subunit sigma (Adaptor AP-2 17 kDa protein) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Sigma2-adaptin)
Gene: AP17

Interactor 2: AP2A1 (Q8LPL6)
AP-2 complex subunit alpha-1 (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin 1) (Clathrin assembly protein complex 2 alpha large chain 1) (At-a-Ad) (At-alpha-Ad)
Gene: ALPHA-ADR

Species: Arabidopsis thaliana

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23975899
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 142 At			1 1012
+	Hs
		321516 AP2S1_HUMAN (1-142): 8.08e-46: 147: 61.27		AP2A1_HUMAN (3-971): 0: 791: 36.35
+	Hs
		302125 AP2S1_HUMAN (1-142): 8.08e-46: 147: 61.27		AP2A2_HUMAN (3-971): 0: 763: 37.14
+	Hs
		903681 AP1S1_HUMAN (1-142): 2.97e-54: 169: 45.78		AP2B1_HUMAN (30-971): 0: 705: 15.55
+	Hs
		880408 AP1S2_HUMAN (2-142): 1.87e-53: 167: 48.94		AP2B1_HUMAN (30-971): 0: 705: 15.55
+	Hs
		903682 AP1S1_HUMAN (1-142): 2.97e-54: 169: 45.78		AP1B1_HUMAN (30-965): 0: 696: 16.43
+	Hs
		925978 AP1S3_HUMAN (1-142): 1.19e-50: 159: 46.48		AP2B1_HUMAN (30-971): 0: 705: 15.55
+	Hs
		880409 AP1S2_HUMAN (2-142): 1.87e-53: 167: 48.94		AP1B1_HUMAN (30-965): 0: 696: 16.43
+	Hs
		1014066 AP1S3_HUMAN (1-142): 1.19e-50: 159: 46.48		AP1B1_HUMAN (30-965): 0: 696: 16.43
+	Hs
		212614 AP1S1_HUMAN (1-142): 2.97e-54: 169: 45.78		AP1G1_HUMAN (7-842): 0: 616: 24.42
+	Hs
		212611 AP1S2_HUMAN (2-142): 1.87e-53: 167: 48.94		AP1G1_HUMAN (7-842): 0: 616: 24.42
+	Hs
		212659 AP1S3_HUMAN (1-142): 1.19e-50: 159: 46.48		AP1G1_HUMAN (7-842): 0: 616: 24.42
+	Hs
		212608 AP2S1_HUMAN (1-142): 8.08e-46: 147: 61.27		AP1G1_HUMAN (7-842): 0: 616: 24.42
+	At
		1196570 AP2S_ARATH (1-142): 1.96e-48: 154: 100.00		APBLB_ARATH (30-967): 0: 606: 16.25
+	Dm
		1362881 Q9VCF4_DROME (1-142): 1.35e-54: 170: 43.66		Q9W388_DROME (2-593): 0: 589: 26.78
+	Dm
		1182762 Q9VCF4_DROME (1-142): 1.35e-54: 170: 43.66		Q7KVR8_DROME (2-593): 0: 584: 26.51
+	Hs
		276362 AP1S1_HUMAN (1-142): 2.97e-54: 169: 45.78		AP1G2_HUMAN (7-736): 1.23e-179: 544: 26.34
+	Hs
		276360 AP1S2_HUMAN (2-142): 1.87e-53: 167: 48.94		AP1G2_HUMAN (7-736): 1.23e-179: 544: 26.34
+	Hs
		276385 AP1S3_HUMAN (1-142): 1.19e-50: 159: 46.48		AP1G2_HUMAN (7-736): 1.23e-179: 544: 26.34
+	Hs
		150247 AP3S1_HUMAN (1-142): 1.28e-53: 168: 41.22		AP3D1_HUMAN (5-742): 4.08e-145: 464: 21.27
+	Hs
		150196 AP3S2_HUMAN (1-142): 3.93e-51: 162: 39.19		AP3D1_HUMAN (5-742): 4.08e-145: 464: 21.27