HitPredict

Interactor 1: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 350
+	Hs
		718164 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Hs
		717977 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		717488 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718406 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1108511 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		717489 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		717887 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1197586 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		718150 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197566 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Mm
		1112809 PCGF5_MOUSE (1-256): 2.03e-64: 203: 96.09		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		584870 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RO52_HUMAN (121-311): 4.15e-35: 135: 17.79
+	Hs
		1197582 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Dr
		1186371 BMI1B_DANRE (1-230): 1.36e-57: 188: 28.69		RING2_DANRE (105-303): 2.8e-32: 125: 15.63
+	Hs
		717765 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		TRI26_HUMAN (121-315): 1.51e-31: 126: 19.90
+	Hs
		718129 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		987986 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Hs
		282521 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RNF8_HUMAN (74-217): 4.44e-28: 115: 24.16
+	Hs
		717742 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96