Interactor 1: SYVN1 (Q86TM6)
E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
Gene: SYVN1

Interactor 2: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 0.60 0.733

The method score is based on:

Property Details
Experiments 29743537, 16289116, 24807418, 16186510, 19864457, 23867461
Identification Methods biochemical, affinity chromatography technology, pull down
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0030970 - retrograde protein transport, ER to cytosol
and 5 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 617
Hs

1 251
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Sc
+ Sc

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Last updated: 15 Jul 2024