HitPredict

Interactor 1: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	24981860, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 359
+	Hs
		899923 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Mm
		899939 LDB1_MOUSE (1-411): 0: 760: 99.76		ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91
+	Mm
		899945 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX5_MOUSE (26-358): 3.66e-59: 197: 26.63
+	Hs
		839771 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		1199143 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX9_HUMAN (10-313): 6.31e-57: 192: 26.33
+	Hs
		903745 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Mm
		903798 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO4_MOUSE (15-165): 1.69e-54: 178: 38.13
+	Hs
		1199126 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Mm
		936878 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO3_MOUSE (27-148): 1.53e-26: 104: 40.16
+	Hs
		638528 LDB1_HUMAN (1-411): 0: 760: 100.00		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Mm
		864804 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX4_MOUSE (1-82): 2.78e-17: 84.3: 22.89
+	Hs
		1199128 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Mm
		291994 LDB1_MOUSE (1-411): 0: 760: 99.76		LMX1B_MOUSE (7-83): 1.26e-16: 82.3: 19.48
+	Hs
		238112 LDB1_HUMAN (1-411): 0: 760: 100.00		LMX1B_HUMAN (7-83): 1.54e-16: 82: 19.48
+	Hs
		1199146 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Mm
		839896 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX3_MOUSE (1-82): 6.09e-14: 74.3: 20.48
+	Hs
		822644 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Mm
		925846 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX1_MOUSE (7-81): 9.27e-14: 73.9: 19.74
+	Hs
		1148473 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX8_HUMAN (7-81): 1.2e-12: 70: 20.00
+	Hs
		1199149 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00