Protein: PKHO1
Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)

Gene: PKHO1, PLEKHO1
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q53GL0

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007520 - myoblast fusion
GO:0008360 - regulation of cell shape
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199126

PKHO1
Pleckstrin homology domain-containing family O member 1

2

1

Small-scale

0.800

High

249756

DOK2
Docking protein 2

2

0

High-throughput

0.770

High

728277

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.756

High

728594

AKT2
RAC-beta serine/threonine-protein kinase

1

2

Small-scale

0.747

High

997762

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.740

High

1199154

SMUF1
E3 ubiquitin-protein ligase SMURF1

6

0

Small-scale

0.708

High

1199157

NLE1
Notchless protein homolog 1

2

0

High-throughput

0.679

High

866707

CAZA2
F-actin-capping protein subunit alpha-2

4

3

High-throughput

0.630

High

867181

CAPZB
F-actin-capping protein subunit beta

4

1

High-throughput

0.630

High

1125343

FLNC
Filamin-C

2

1

High-throughput

0.628

High

1130752

RRP5
Protein RRP5 homolog

2

1

High-throughput

0.628

High

374653

RASH
GTPase HRas

1

3

High-throughput

0.618

High

375575

RASK
GTPase KRas

1

3

High-throughput

0.618

High

48359

UBA6
Ubiquitin-like modifier-activating enzyme 6

2

0

High-throughput

0.602

High

188493

NVL
Nuclear valosin-containing protein-like

2

0

High-throughput

0.602

High

899943

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.602

High

1199131

TRM1L
tRNA

2

0

High-throughput

0.602

High

1199133

CENPV
Centromere protein V

2

0

High-throughput

0.602

High

1199138

DDX51
ATP-dependent RNA helicase DDX51

2

0

High-throughput

0.602

High

1199151

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.602

High

1199153

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

0

High-throughput

0.602

High

1199162

NOC2L
Nucleolar complex protein 2 homolog

2

0

High-throughput

0.602

High

1199142

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

0

High-throughput

0.598

High

1199161

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

Small-scale

0.595

High

327289

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.580

High

1005394

CP4F2
Cytochrome P450 4F2

2

0

High-throughput

0.580

High

1092007

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

0

High-throughput

0.580

High

968943

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.576

High

915102

CAZA1
F-actin-capping protein subunit alpha-1

2

3

High-throughput

0.574

High

1199127

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

2

1

High-throughput

0.574

High

1199129

SPT2
Protein SPT2 homolog

2

1

High-throughput

0.574

High

1199163

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.561

High

373971

RASN
GTPase NRas

1

3

High-throughput

0.553

High

1199145

SMAD5
Mothers against decapentaplegic homolog 5

1

0

Small-scale

0.537

High

130491

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

345906

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.513

High

810142

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.513

High

859313

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

1199141

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.513

High

1199146

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1199155

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

278098

FLNB
Filamin-B

1

1

High-throughput

0.508

High

1009795

IN35
Interferon-induced 35 kDa protein

1

2

High-throughput

0.508

High

679177

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.486

High

954151

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.486

High

1199152

PAAT
ATPase PAAT

1

0

High-throughput

0.486

High

185754

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1065903

Q08AM2
ADAM33 protein

1

1

High-throughput

0.470

High

1196841

Q4VAQ0
COL8A2 protein

1

1

High-throughput

0.470

High

668783

CO8A2
Collagen alpha-2(VIII) chain

1

1

High-throughput

0.439

High

1199148

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.439

High

1041827

CENPC
Centromere protein C

1

0

High-throughput

0.426

High

1119159

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1199136

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1099380

SRSF6
Serine/arginine-rich splicing factor 6

1

1

High-throughput

0.407

High

61944

GTPBA
GTP-binding protein 10

2

0

High-throughput

0.328

High

244367

NPA1P
Nucleolar pre-ribosomal-associated protein 1

2

0

High-throughput

0.328

High

319102

SC24D
Protein transport protein Sec24D

2

0

High-throughput

0.328

High

1199135

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.328

High

1199147

GTPB2
GTP-binding protein 2

2

0

High-throughput

0.328

High

1199159

RL26L
Ribosomal protein uL24-like

2

0

High-throughput

0.318

High

60570

TM218
Transmembrane protein 218

2

0

High-throughput

0.316

High

378112

TNFA
Tumor necrosis factor

2

0

High-throughput

0.316

High

1149871

PAQRB
Monocyte to macrophage differentiation factor

2

0

High-throughput

0.316

High

1154634

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.316

High

1199128

TSPO2
Translocator protein 2

2

0

High-throughput

0.316

High

1199130

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.316

High

1199132

LRP10
Low-density lipoprotein receptor-related protein 10

2

0

High-throughput

0.316

High

1199134

TSN33
Tetraspanin-33

2

0

High-throughput

0.316

High

1199137

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.316

High

1199140

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.316

High

1199143

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.316

High

1199150

SNAB
Beta-soluble NSF attachment protein

2

0

High-throughput

0.316

High

1199160

T3JAM
TRAF3-interacting JNK-activating modulator

2

0

High-throughput

0.316

High

1193326

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.279

Low

1199139

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.279

Low

1199144

ODAD1
Outer dynein arm-docking complex subunit 1

1

0

High-throughput

0.279

Low

1199156

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.279

Low

1199158

RBM28
RNA-binding protein 28

1

0

High-throughput

0.279

Low

1142290

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.269

Low

1199149

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

0

High-throughput

0.268

Low

255054

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

298266

BODG
Gamma-butyrobetaine dioxygenase

1

0

High-throughput

0.232

Low

350298

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.232

Low

517231

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025