HitPredict

Interactor 1: MARH3 (Q86UD3)
E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3)
Gene: MARCHF3

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 253 Hs			1 151
+	Hs
		1199325 MARH3_HUMAN (1-253): 9.07e-97: 285: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		919767 MARH3_HUMAN (1-253): 9.07e-97: 285: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895832 MARH3_HUMAN (1-253): 9.07e-97: 285: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1199317 MARH3_HUMAN (1-253): 9.07e-97: 285: 100.00		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		851833 MARH3_HUMAN (1-253): 9.07e-97: 285: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		849466 MARH2_HUMAN (1-253): 6.27e-79: 239: 64.03		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		851897 MARH2_HUMAN (1-253): 6.27e-79: 239: 64.03		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		849378 MARH1_HUMAN (10-231): 1.44e-52: 173: 24.08		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		849469 MARH4_HUMAN (69-251): 4.17e-51: 173: 22.04		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		849338 MARH8_HUMAN (59-241): 1.3e-45: 156: 25.13		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		895806 MARH8_HUMAN (59-241): 1.3e-45: 156: 25.13		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		231862 MARH6_HUMAN (67-230): 1.9e-36: 138: 20.90		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		231880 MARH6_HUMAN (67-230): 1.9e-36: 138: 20.90		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		849461 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919880 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895930 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1282354 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851894 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1291149 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		Q96FI0_HUMAN (1-148): 1.13e-62: 191: 97.30
+	Hs
		1284891 MARH5_HUMAN (71-242): 3.71e-32: 120: 19.37		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00