HitPredict - High confidence protein-protein interactions

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	20547845, 20067962
Identification Methods	surface plasmon resonance, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001530 - lipopolysaccharide binding GO:0006954 - inflammatory response GO:0009986 - cell surface GO:0032689 - negative regulation of type II interferon production GO:0032732 - positive regulation of interleukin-1 production and 11 others more... GO:0032733 - positive regulation of interleukin-10 production GO:0032735 - positive regulation of interleukin-12 production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0071222 - cellular response to lipopolysaccharide GO:2000343 - positive regulation of chemokine (C-X-C motif) ligand 2 production
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	839
Hs

1	215

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Last updated: 15 Jul 2024