HitPredict

Interactor 1: SKAP1 (Q86WV1)
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Gene: SKAP1

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 923
+	Hs
		1153279 PKHA7_HUMAN (57-290): 7.79e-35: 137: 14.02		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Hs
		1217987 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Hs
		411781 SKAP1_HUMAN (1-359): 2.76e-125: 366: 100.00		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Dm
		1096609 Q7KNQ9_DROME (79-260): 7.06e-36: 140: 18.13		Q24170_DROME (43-899): 5.4e-169: 519: 30.29
+	Dm
		1096611 Q7KNQ9_DROME (79-260): 7.06e-36: 140: 18.13		Q24171_DROME (43-899): 3.76e-169: 519: 30.29
+	Mm
		411926 SKAP2_MOUSE (6-356): 3.66e-104: 312: 43.54		LCK_MOUSE (591-890): 1.05e-98: 320: 23.93
+	Hs
		269510 SKAP2_HUMAN (6-356): 5.24e-102: 306: 43.58		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		269519 SKAP2_HUMAN (6-356): 5.24e-102: 306: 43.58		FRK_HUMAN (603-895): 4.71e-98: 318: 22.67
+	Hs
		665661 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		872491 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15
+	Hs
		1072602 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		EPHA7_HUMAN (215-914): 9.83e-149: 467: 14.59
+	Hs
		374648 CNKR1_HUMAN (73-272): 3.1e-41: 155: 20.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		374608 CNKR2_HUMAN (56-301): 1.55e-37: 145: 17.72		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		600712 PKHA6_HUMAN (71-293): 1.58e-35: 139: 16.59		EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72
+	Hs
		600673 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72
+	Dm
		507724 Q7KNQ9_DROME (79-260): 7.06e-36: 140: 18.13		KRAF1_DROME (251-908): 5.23e-117: 376: 20.48
+	Hs
		411897 PKHA6_HUMAN (71-293): 1.58e-35: 139: 16.59		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411764 PKHA7_HUMAN (57-290): 7.79e-35: 137: 14.02		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411861 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		788974 TEC_HUMAN (106-351): 1.55e-32: 130: 17.06		FRK_HUMAN (603-895): 4.71e-98: 318: 22.67