Protein: HEAT1
HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]

Gene: HEAT1, HEATR1
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q9H583

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

347892

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.622

High

305031

DUS14
Dual specificity protein phosphatase 14

2

0

High-throughput

0.602

High

1028278

SBP1
Methanethiol oxidase

2

0

High-throughput

0.602

High

205983

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.585

High

1331927

CAH14
Carbonic anhydrase 14

2

0

High-throughput

0.585

High

603714

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

High-throughput

0.584

High

916859

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

1029872

TIF1B
Transcription intermediary factor 1-beta

2

1

Small-scale

0.584

High

1331929

TN13B
Tumor necrosis factor ligand superfamily member 13B

2

1

High-throughput

0.584

High

1257248

LRC15
Leucine-rich repeat-containing protein 15

2

1

High-throughput

0.574

High

370433

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1331915

ANLN
Anillin

2

0

High-throughput

0.559

High

1030759

SLAF1
Signaling lymphocytic activation molecule

2

2

High-throughput

0.558

High

1318471

CD244
Natural killer cell receptor 2B4

2

2

High-throughput

0.558

High

50246

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.536

High

172222

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

355057

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.536

High

488382

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

726410

BASI
Basigin

1

1

High-throughput

0.536

High

877635

FOXG1
Forkhead box protein G1

1

4

High-throughput

0.536

High

1021254

FOXI1
Forkhead box protein I1

1

4

High-throughput

0.536

High

1218377

WDR75
WD repeat-containing protein 75

1

6

High-throughput

0.536

High

1302130

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.536

High

1331930

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.536

High

1191354

ARHG8
Neuroepithelial cell-transforming gene 1 protein

2

1

High-throughput

0.521

High

1233858

ARG39
Rho guanine nucleotide exchange factor 39

2

2

High-throughput

0.521

High

556528

LEUK
Leukosialin

1

0

High-throughput

0.513

High

595568

GRAH
Granzyme H

1

0

High-throughput

0.513

High

646302

STOM
Stomatin

1

0

High-throughput

0.513

High

702799

CADH5
Cadherin-5

1

0

High-throughput

0.513

High

943756

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.513

High

957481

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.513

High

1185633

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1202552

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

1233039

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1253029

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1254656

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1328347

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

1331912

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

1331925

CLC2D
C-type lectin domain family 2 member D

1

0

High-throughput

0.513

High

1224410

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.508

High

1136506

TTBK1
Tau-tubulin kinase 1

1

0

High-throughput

0.493

High

126478

FOXE1
Forkhead box protein E1

1

4

High-throughput

0.489

High

126649

P2Y10
Putative P2Y purinoceptor 10

1

7

High-throughput

0.489

High

198131

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

270835

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

310815

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.489

High

639645

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.489

High

782474

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.489

High

876195

PAR2
Proteinase-activated receptor 2

1

6

High-throughput

0.489

High

989754

TNR9
Tumor necrosis factor receptor superfamily member 9

1

1

High-throughput

0.489

High

1021349

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

1031078

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

6

High-throughput

0.489

High

1202738

P2RY8
P2Y purinoceptor 8

1

6

High-throughput

0.489

High

1204518

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

2

High-throughput

0.489

High

1306866

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1318640

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.489

High

1331914

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1331922

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

1331935

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1230717

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.481

High

338980

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.479

High

133672

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

244938

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

268285

EED
Polycomb protein EED

1

5

High-throughput

0.479

High

309068

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

668984

PML
Protein PML

1

1

High-throughput

0.479

High

718199

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

740599

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.479

High

788914

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.479

High

808932

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

894432

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

903519

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

917922

H4
Histone H4

1

1

High-throughput

0.479

High

918689

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

920344

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

922384

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

966480

EXOSX
Exosome complex component 10

1

1

High-throughput

0.479

High

969990

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1018053

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

1054590

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1064151

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1147529

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.479

High

1221736

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1244492

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1260296

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.479

High

1264188

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

1269615

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1282708

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

3

High-throughput

0.479

High

1288305

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1304104

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1313167

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1315857

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1316876

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.479

High

1318328

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.479

High

1326409

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1326740

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1331913

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

1331916

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1331918

NLE1
Notchless protein homolog 1

1

3

High-throughput

0.479

High

1331920

AATF
Protein AATF

1

1

High-throughput

0.479

High

260609

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.470

High

123004

MEN1
Menin

1

0

High-throughput

0.458

High

149288

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

179818

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

210279

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

233633

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

258196

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

323134

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

455874

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

488805

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.458

High

530751

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

553708

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652246

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

652991

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

685028

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

721441

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

742538

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

818466

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

824381

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

832718

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

875320

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

941431

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1027261

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1033556

ILK
Integrin-linked protein kinase

1

0

High-throughput

0.458

High

1036081

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1040951

MTMR3
Myotubularin-related protein 3

1

0

High-throughput

0.458

High

1042538

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1063623

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1066696

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1085679

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1085951

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1148785

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1200666

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1201675

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1251024

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1256399

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1285760

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1294002

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1316747

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1328248

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1331919

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1331921

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1331923

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1331931

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1331932

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

354557

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

484331

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

2

High-throughput

0.445

High

1057651

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1161008

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

1

High-throughput

0.439

High

1331917

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

246390

SCN2B
Sodium channel subunit beta-2

1

2

High-throughput

0.437

High

297675

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

900903

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

901243

RND3
Rho-related GTP-binding protein RhoE

1

2

High-throughput

0.437

High

965842

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1067138

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

1067616

P2RY6
P2Y purinoceptor 6

1

7

High-throughput

0.437

High

1222100

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1315148

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1328589

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

1331282

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

402472

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

968222

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

484479

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.407

High

1237383

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.328

High

1331928

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

848961

AL3A2
Aldehyde dehydrogenase family 3 member A2

2

0

High-throughput

0.318

High

780103

CCNF
Cyclin-F

2

0

High-throughput

0.305

High

581863

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

1169983

RHG36
Rho GTPase-activating protein 36

2

0

High-throughput

0.298

High

131964

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

161576

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.279

Low

238922

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

353089

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

535570

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.279

Low

702297

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

783740

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.279

Low

957934

EFNB1
Ephrin-B1

1

0

High-throughput

0.279

Low

1083601

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1153740

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1166225

VSTM1
V-set and transmembrane domain-containing protein 1

1

0

High-throughput

0.279

Low

1185043

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

0

High-throughput

0.279

Low

1254051

PKR1
Prokineticin receptor 1

1

0

High-throughput

0.279

Low

1271760

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1288032

HDA11
Histone deacetylase 11

1

0

High-throughput

0.279

Low

1299242

OPALI
Opalin

1

0

High-throughput

0.279

Low

1331924

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1331934

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1104020

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.269

Low

119519

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

232981

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.249

Low

256064

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

385522

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1053656

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1061617

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1101292

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1124456

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1165953

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1171714

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1220391

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

1236193

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low

1310728

PELO
Protein pelota homolog

1

0

High-throughput

0.249

Low

1331926

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1331933

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.249

Low

1241617

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024