HitPredict

Interactor 1: GOLI (Q86XS8)
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)
Gene: RNF130

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36610398
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	zf-RING_2~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016020 - membrane GO:0046872 - metal ion binding GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 419 Hs			1 643
+	Hs
		1240830 RN149_HUMAN (25-343): 1.03e-80: 255: 41.85		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1262541 ZNRF4_HUMAN (6-375): 3.81e-59: 200: 18.95		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1198708 SYVN1_HUMAN (17-312): 1.08e-56: 198: 14.38		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1356609 AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1198614 GOLI_HUMAN (1-419): 4.48e-123: 365: 100.00		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Hs
		1198626 RN149_HUMAN (25-343): 1.03e-80: 255: 41.85		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Hs
		1198608 SYVN1_HUMAN (17-312): 1.08e-56: 198: 14.38		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	At
		1257948 RIN2_ARATH (12-418): 3.1e-47: 172: 11.94		RIN2_ARATH (68-538): 2.37e-93: 301: 21.37
+	At
		1257949 RIN2_ARATH (12-418): 3.1e-47: 172: 11.94		RIN3_ARATH (68-538): 2.03e-90: 293: 20.98
+	Hs
		1259698 ZNRF4_HUMAN (6-375): 3.81e-59: 200: 18.95		RN139_HUMAN (84-407): 7.91e-67: 232: 17.52
+	Zm
		9258 A0A1D6EVN7_MAIZE (145-418): 1.38e-35: 140: 14.06		A0A1D6EVN7_MAIZE (65-538): 8.38e-82: 272: 18.42
+	Hs
		1255974 RN128_HUMAN (1-384): 4.57e-89: 278: 36.90		RN128_HUMAN (260-411): 9.48e-22: 100: 15.34
+	Hs
		1240693 RN149_HUMAN (25-343): 1.03e-80: 255: 41.85		RN128_HUMAN (260-411): 9.48e-22: 100: 15.34
+	Hs
		1240704 RN149_HUMAN (25-343): 1.03e-80: 255: 41.85		RN133_HUMAN (265-412): 9.02e-22: 99.5: 17.16
+	Mm
		1321933 AMFR_MOUSE (2-346): 3.44e-43: 162: 13.50		MGRN1_MOUSE (303-626): 2.73e-48: 179: 16.62
+	Hs
		230180 AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50		MGRN1_HUMAN (303-624): 2.06e-40: 157: 17.31
+	Zm
		75290 B4FHZ7_MAIZE (230-375): 5.57e-27: 111: 22.60		B4FRI2_MAIZE (335-642): 3.4e-32: 130: 12.46
+	At
		1340218 ATL55_ARATH (231-410): 1.4e-28: 115: 22.10		ATL55_ARATH (338-439): 3.53e-27: 113: 28.44