Protein: MKS3
Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67)

Gene: MKS3, TMEM67
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q5HYA8

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0005813 - centrosome
GO:0010826 - negative regulation of centrosome duplication
GO:0030659 - cytoplasmic vesicle membrane
GO:0031005 - filamin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1204909

AT1B4
Protein ATP1B4

3

1

High-throughput

0.609

High

1204890

TECT2
Tectonic-2

2

0

High-throughput

0.602

High

548029

PSPC
Surfactant protein C

2

0

Small-scale

0.585

High

351685

SG1D1
Secretoglobin family 1D member 1

2

1

High-throughput

0.574

High

1204868

TM11B
Transmembrane protease serine 11B

2

2

High-throughput

0.574

High

1204891

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.574

High

170793

CLGN
Calmegin

1

1

High-throughput

0.536

High

437698

HEPS
Serine protease hepsin

1

2

High-throughput

0.536

High

698734

CALX
Calnexin

1

1

High-throughput

0.536

High

1168731

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1204900

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1204910

HYOU1
Hypoxia up-regulated protein 1

1

0

High-throughput

0.513

High

380298

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

5

High-throughput

0.489

High

380439

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

6

High-throughput

0.489

High

420806

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.489

High

438889

CD1A
T-cell surface glycoprotein CD1a

1

4

High-throughput

0.489

High

520873

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

586183

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

1

4

High-throughput

0.489

High

607377

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.489

High

700786

DMB
HLA class II histocompatibility antigen, DM beta chain

1

4

High-throughput

0.489

High

702399

CYTD
Cystatin-D

1

1

High-throughput

0.489

High

705960

CD1B
T-cell surface glycoprotein CD1b

1

4

High-throughput

0.489

High

1009149

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

6

High-throughput

0.489

High

1187196

CC50B
Cell cycle control protein 50B

1

1

High-throughput

0.489

High

1204863

IGFL1
Insulin growth factor-like family member 1

1

1

High-throughput

0.489

High

1204864

IGFL3
Insulin growth factor-like family member 3

1

1

High-throughput

0.489

High

1204865

SG1D4
Secretoglobin family 1D member 4

1

1

High-throughput

0.489

High

1204867

TAFA5
Chemokine-like protein TAFA-5

1

2

High-throughput

0.489

High

1204871

TAFA2
Chemokine-like protein TAFA-2

1

2

High-throughput

0.489

High

1204894

WFDC6
WAP four-disulfide core domain protein 6

1

1

High-throughput

0.489

High

1204899

CST11
Cystatin-11

1

1

High-throughput

0.489

High

1204904

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.489

High

1204911

ST14
Suppressor of tumorigenicity 14 protein

1

2

High-throughput

0.489

High

1204908

UBQL1
Ubiquilin-1

1

1

High-throughput

0.481

High

975423

PRS10
26S proteasome regulatory subunit 10B

1

2

High-throughput

0.479

High

292650

RENR
Renin receptor

1

0

High-throughput

0.458

High

321256

ERLN2
Erlin-2

1

0

High-throughput

0.458

High

417478

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

469093

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

535149

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

878665

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

High-throughput

0.458

High

903946

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

956063

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.458

High

956326

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.458

High

994920

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.458

High

1058450

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1113290

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1136117

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

1136225

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1155221

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

1191761

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.458

High

1204869

VRK2
Serine/threonine-protein kinase VRK2

1

0

High-throughput

0.458

High

1204872

VMA12
Vacuolar ATPase assembly protein VMA12

1

0

High-throughput

0.458

High

1204874

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1204877

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.458

High

1204878

SPP
Signal peptide peptidase

1

0

High-throughput

0.458

High

1204884

UBXN4
UBX domain-containing protein 4

1

0

High-throughput

0.458

High

1204887

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1204897

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1204898

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.458

High

1204901

SEC12
Guanine nucleotide-exchange factor SEC12

1

0

High-throughput

0.458

High

1204906

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.458

High

218269

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

610360

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.437

High

851342

PRS6B
26S proteasome regulatory subunit 6B

1

2

High-throughput

0.437

High

968947

PRS8
26S proteasome regulatory subunit 8

1

2

High-throughput

0.437

High

1098018

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.437

High

1204893

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.437

High

380552

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

4

High-throughput

0.407

High

332649

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

689829

CD27
CD27 antigen

3

0

High-throughput

0.347

High

1144604

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

0

High-throughput

0.347

High

1204870

S22A9
Organic anion transporter 7

3

0

High-throughput

0.345

High

252215

ISK4
Serine protease inhibitor Kazal-type 4

2

0

High-throughput

0.328

High

947993

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.328

High

1204859

DB121
Beta-defensin 121

2

0

High-throughput

0.328

High

1204866

LYZL2
Lysozyme-like protein 2

2

0

High-throughput

0.328

High

1204892

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

2

0

High-throughput

0.328

High

1204896

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

0

High-throughput

0.328

High

1204902

NRN1
Neuritin

2

0

High-throughput

0.328

High

1204881

SYNE2
Nesprin-2

1

0

Small-scale

0.292

High

64362

CDHR4
Cadherin-related family member 4

1

0

High-throughput

0.279

Low

139226

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

337176

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

342579

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

465849

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.279

Low

506849

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

549787

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

575659

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

590296

MUC1
Mucin-1

1

0

High-throughput

0.279

Low

749210

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

855329

5HT3A
5-hydroxytryptamine receptor 3A

1

0

High-throughput

0.279

Low

1025919

NDP
Norrin

1

0

High-throughput

0.279

Low

1181019

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1181040

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

1181062

DB110
Beta-defensin 110

1

0

High-throughput

0.279

Low

1193244

CLM2
CMRF35-like molecule 2

1

0

High-throughput

0.279

Low

1204862

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1204873

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

1204875

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.279

Low

1204880

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.279

Low

1204882

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.279

Low

1204883

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.279

Low

1204888

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.279

Low

1204889

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

1204895

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

1204903

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.279

Low

1204907

BTNL2
Butyrophilin-like protein 2

1

0

High-throughput

0.279

Low

422264

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.268

Low

138145

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

181332

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.249

Low

190014

TOX3
TOX high mobility group box family member 3

1

0

High-throughput

0.249

Low

338134

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.249

Low

701837

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.249

Low

724096

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.249

Low

869601

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.249

Low

902994

MMP15
Matrix metalloproteinase-15

1

0

High-throughput

0.249

Low

933656

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.249

Low

1043860

KCNC4
Voltage-gated potassium channel KCNC4

1

0

High-throughput

0.249

Low

1130753

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.249

Low

1204860

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.249

Low

1204876

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1204879

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.249

Low

1204885

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1204886

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.249

Low

1204905

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

222282

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

1181070

DB109
Beta-defensin 109B

1

0

High-throughput

0.232

Low

1204861

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025