HitPredict

Interactor 1: FRAS1 (Q86XX4)
Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)
Gene: FRAS1

Interactor 2: ATS17 (Q8TE56)
A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-)
Gene: ADAMTS17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4008 Hs			1 1095
+	Hs
		257274 FRAS1_HUMAN (1-4008): 0: 2806: 100.00		ATS4_HUMAN (69-767): 8.96e-132: 422: 29.93
+	Hs
		1132290 FREM2_HUMAN (1296-3338): 2.12e-108: 393: 18.62		ATS17_HUMAN (1-1095): 0: 776: 100.00
+	Hs
		980468 NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53		ATS17_HUMAN (1-1095): 0: 776: 100.00
+	Hs
		1255812 AGRV1_HUMAN (1121-3205): 1.27e-35: 153: 12.28		ATS17_HUMAN (1-1095): 0: 776: 100.00
+	Mm
		93226 PCD16_MOUSE (1204-3149): 0: 808: 10.10		ATS1_MOUSE (975-1092): 7.53e-09: 62.3: 23.73
+	Hs
		1255816 CELR2_HUMAN (985-1093): 1.37e-10: 70.4: 16.36		ATS17_HUMAN (1-1095): 0: 776: 100.00
+	Hs
		1349597 PCDAB_HUMAN (2317-3064): 1.61e-89: 318: 8.64		ADA22_HUMAN (12-716): 3.92e-111: 369: 16.40
+	Hs
		1132286 FREM2_HUMAN (1296-3338): 2.12e-108: 393: 18.62		ATS13_HUMAN (732-1092): 2.51e-19: 96.6: 15.52
+	Hs
		1253280 NOTC3_HUMAN (4-433): 4.53e-19: 98.1: 14.23		ADA32_HUMAN (72-715): 3.31e-99: 333: 15.07
+	Hs
		980561 NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53		ATS9_HUMAN (485-1083): 8.74e-39: 160: 17.33
+	Hs
		980469 NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53		ATS15_HUMAN (968-1092): 2.86e-10: 66.9: 20.00
+	Hs
		980569 NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53		ATS1_HUMAN (976-1092): 1.39e-09: 64.6: 17.95
+	Ce
		107288 G5EF34_CAEEL (580-1099): 4.54e-11: 71.4: 15.74		ADT2_CAEEL (554-1091): 2.97e-27: 121: 14.80
+	Hs
		1166947 PCSK5_HUMAN (847-1155): 3.35e-26: 121: 22.75		ATL4_HUMAN (527-891): 1.38e-09: 64.4: 22.03
+	Hs
		1176301 CELR2_HUMAN (985-1093): 1.37e-10: 70.4: 16.36		ATS13_HUMAN (732-1092): 2.51e-19: 96.6: 15.52
+	Ce
		104588 G5EBZ2_CAEEL (38-157): 2.83e-11: 72.2: 26.83		PPN1_CAEEL (552-924): 1.2e-18: 94.5: 18.81
+	Ce
		107281 G5EF34_CAEEL (580-1099): 4.54e-11: 71.4: 15.74		PPN1_CAEEL (552-924): 1.2e-18: 94.5: 18.81
+	Ce
		104611 G5EBZ2_CAEEL (38-157): 2.83e-11: 72.2: 26.83		Q7Z291_CAEEL (768-1091): 2.42e-18: 93.1: 15.92
+	Hs
		1166987 CHRD_HUMAN (90-280): 6.28e-15: 84.3: 32.11		ATL4_HUMAN (527-891): 1.38e-09: 64.4: 22.03
+	Dm
		706606 FAT_DROME (283-411): 2.39e-10: 69.7: 11.11		Q0E8N3_DROME (870-1040): 2.42e-11: 70.5: 28.16