HitPredict

Interactor 1: FXL21 (Q8BFZ4)
F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)
Gene: Fbxl21

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.744

Property	Details
Experiments	32937135, 23452855
Identification Methods	protein complementation assay, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 434 Mm			1 163
+	Hs
		929114 FXL21_HUMAN (1-434): 0: 761: 85.95		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929115 FBXL3_HUMAN (30-434): 0: 733: 76.79		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1207953 FBXL3_MOUSE (17-434): 0: 727: 74.64		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00