Protein: VPS35
Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)

Gene: VPS35
Organism: Homo sapiens
Interactions: 238
UniProt ID: Q96QK1

Gene Ontology (top 5):
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

264737

VP26A
Vacuolar protein sorting-associated protein 26A

18

10

Small-scale

0.988

High

1300508

VPS29
Vacuolar protein sorting-associated protein 29

17

6

Small-scale

0.988

High

1116285

VP26B
Vacuolar protein sorting-associated protein 26B

8

10

Small-scale

0.970

High

1267952

TBCD5
TBC1 domain family member 5

6

2

Small-scale

0.729

High

234983

SNX3
Sorting nexin-3

4

8

Small-scale

0.704

High

1300519

WAC2C
WASH complex subunit 2C

4

1

Small-scale

0.699

High

845183

RAB7A
Ras-related protein Rab-7a

3

5

Small-scale

0.660

High

1298917

ANR27
Ankyrin repeat domain-containing protein 27

3

1

Small-scale

0.643

High

709016

MCM7
DNA replication licensing factor MCM7

3

0

High-throughput

0.638

High

1300501

GDAP2
Ganglioside-induced differentiation-associated protein 2

3

0

Small-scale

0.634

High

66305

WASH1
WASH complex subunit 1

3

2

Small-scale

0.633

High

1296867

SNX27
Sorting nexin-27

3

0

Small-scale

0.622

High

1300480

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.618

High

228421

PRKN
E3 ubiquitin-protein ligase parkin

3

0

Small-scale

0.613

High

1145074

WAC2A
WASH complex subunit 2A

2

1

Small-scale

0.601

High

1300512

ANR50
Ankyrin repeat domain-containing protein 50

2

1

Small-scale

0.601

High

395544

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.585

High

1015869

WASC5
WASH complex subunit 5

2

0

Small-scale

0.576

High

1101822

WASC4
WASH complex subunit 4

2

0

Small-scale

0.576

High

1132668

FKB15
FK506-binding protein 15

2

0

Small-scale

0.576

High

1286526

ENTR1
Endosome-associated-trafficking regulator 1

2

0

Small-scale

0.576

High

600735

DRD1
D(1A) dopamine receptor

1

1

Small-scale

0.561

High

825731

MTR1B
Melatonin receptor type 1B

2

1

Small-scale

0.558

High

68621

A8MY26
VPS26 endosomal protein sorting factor C

1

0

Small-scale

0.546

High

181731

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

1

High-throughput

0.536

High

215543

CF410
Cilia- and flagella-associated protein 410

1

1

High-throughput

0.536

High

256000

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.536

High

363268

FINC
Fibronectin

1

1

High-throughput

0.536

High

813137

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

857197

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.536

High

1139625

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.536

High

1189725

MYCPP
C-myc promoter-binding protein

1

1

High-throughput

0.536

High

1285640

ARL8A
ADP-ribosylation factor-like protein 8A

1

2

High-throughput

0.536

High

1300482

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.536

High

1300500

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.536

High

1300505

ANFY1
Rabankyrin-5

1

1

Small-scale

0.536

High

1300514

SNX12
Sorting nexin-12

1

8

High-throughput

0.536

High

128623

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.529

High

1202249

LCA5
Lebercilin

2

1

High-throughput

0.521

High

549579

VEGFA
Vascular endothelial growth factor A, long form

1

0

High-throughput

0.518

High

1244173

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

1

High-throughput

0.515

High

116894

KIF2A
Kinesin-like protein KIF2A

1

0

High-throughput

0.513

High

200662

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.513

High

201971

WDR62
WD repeat-containing protein 62

1

0

High-throughput

0.513

High

229724

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

270702

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.513

High

298732

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.513

High

416685

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

555606

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

565002

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

565965

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

686039

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

750885

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.513

High

781650

ETV6
Transcription factor ETV6

1

0

High-throughput

0.513

High

813688

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

822132

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.513

High

850590

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.513

High

1068874

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.513

High

1071066

IRF4
Interferon regulatory factor 4

1

0

High-throughput

0.513

High

1078137

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.513

High

1082342

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

1134069

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.513

High

1134933

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1138504

ZN318
Zinc finger protein 318

1

0

High-throughput

0.513

High

1138995

GP107
Protein GPR107

1

0

High-throughput

0.513

High

1158996

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.513

High

1200228

N4BP2
NEDD4-binding protein 2

1

0

High-throughput

0.513

High

1215871

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.513

High

1218174

CEP97
Centrosomal protein of 97 kDa

1

0

High-throughput

0.513

High

1252630

SHKB1
SH3KBP1-binding protein 1

1

0

High-throughput

0.513

High

1255125

DLG5
Disks large homolog 5

1

0

High-throughput

0.513

High

1262605

LMO7
LIM domain only protein 7

1

0

High-throughput

0.513

High

1299968

NEK1
Serine/threonine-protein kinase Nek1

1

0

High-throughput

0.513

High

1300483

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

1300485

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.513

High

1300490

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1300497

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

1300503

SPG21
Maspardin

1

0

High-throughput

0.513

High

1300504

COMD9
COMM domain-containing protein 9

1

0

High-throughput

0.513

High

1300513

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.513

High

1273810

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

617637

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

1101232

CL16A
Protein CLEC16A

1

0

High-throughput

0.493

High

1300489

ZBP1
Z-DNA-binding protein 1

1

0

High-throughput

0.493

High

1127821

LRC73
Leucine-rich repeat-containing protein 73

1

1

High-throughput

0.489

High

1164142

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.489

High

825665

NRAM2
Natural resistance-associated macrophage protein 2

1

0

Small-scale

0.480

High

160161

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.479

High

205857

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

282718

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

385374

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

429108

ADRB2
Beta-2 adrenergic receptor

1

1

Small-scale

0.479

High

530727

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

749793

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

835952

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

998992

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1066557

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1188361

ATG9A
Autophagy-related protein 9A

1

1

Small-scale

0.479

High

1200170

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.479

High

1240731

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1281774

IGSF8
Immunoglobulin superfamily member 8

1

2

High-throughput

0.479

High

1282523

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

Small-scale

0.479

High

1300491

GOLP3
Golgi phosphoprotein 3

1

1

Small-scale

0.479

High

1300493

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1174182

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

2

High-throughput

0.470

High

1296225

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.464

High

119486

LEG9
Galectin-9

1

0

High-throughput

0.458

High

163947

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

347644

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

354540

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

374726

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

400634

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

527730

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

Small-scale

0.458

High

537999

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.458

High

575544

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

610486

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

625569

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

684967

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

719070

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

724269

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

772120

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

779948

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

818371

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

891273

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.458

High

1026346

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.458

High

1035991

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1043175

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1045353

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1064615

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1165874

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1243893

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1267097

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1281328

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1300486

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1300495

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1300502

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1300507

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

1300509

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1300518

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

1300521

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

514888

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

Small-scale

0.457

High

1040506

SNX1
Sorting nexin-1

1

8

Small-scale

0.457

High

86513

WASH3
Putative WAS protein family homolog 3

1

2

Small-scale

0.445

High

241807

CCD22
Coiled-coil domain-containing protein 22

1

1

Small-scale

0.445

High

254228

SLIT3
Slit homolog 3 protein

1

2

Small-scale

0.445

High

257099

DJC13
DnaJ homolog subfamily C member 13

1

1

Small-scale

0.445

High

497463

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

581831

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

601339

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

Small-scale

0.445

High

718122

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1083878

NTRK2
BDNF/NT-3 growth factors receptor

1

2

Small-scale

0.445

High

1130468

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1170238

NBEL1
Neurobeachin-like protein 1

1

1

Small-scale

0.445

High

1223861

AN13A
Ankyrin repeat domain-containing protein 13A

1

2

Small-scale

0.445

High

1262862

STAB2
Stabilin-2

1

1

Small-scale

0.445

High

1264787

TITIN
Titin

1

2

Small-scale

0.445

High

1300487

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1300494

WASH6
WAS protein family homolog 6

1

2

High-throughput

0.445

High

1300499

TBC13
TBC1 domain family member 13

1

2

Small-scale

0.445

High

1300496

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

295150

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

713864

RYK
Tyrosine-protein kinase RYK

1

3

Small-scale

0.437

High

1176259

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1204815

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

1220806

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

1223418

ZDH23
Palmitoyltransferase ZDHHC23

1

2

Small-scale

0.437

High

1296047

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.437

High

1300498

ZDH18
Palmitoyltransferase ZDHHC18

1

1

Small-scale

0.437

High

72932

B4DNL7
cDNA FLJ60737, highly similar to Cysteine desulfurase, mitochondrial

1

0

Small-scale

0.426

High

110746

H3BV68
VPS35 endosomal protein-sorting factor-like

1

0

Small-scale

0.426

High

238727

IMA7
Importin subunit alpha-7

1

0

Small-scale

0.426

High

529596

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

574568

ITB5
Integrin beta-5

1

0

Small-scale

0.426

High

599817

5NTD
5'-nucleotidase

1

0

Small-scale

0.426

High

722675

SPRE
Sepiapterin reductase

1

0

Small-scale

0.426

High

801758

RAGP1
Ran GTPase-activating protein 1

1

0

Small-scale

0.426

High

949152

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

Small-scale

0.426

High

1039407

PKD2
Polycystin-2

1

0

Small-scale

0.426

High

1047798

CKAP5
Cytoskeleton-associated protein 5

1

0

Small-scale

0.426

High

1122608

CCD93
Coiled-coil domain-containing protein 93

1

0

Small-scale

0.426

High

1159517

SCYL2
SCY1-like protein 2

1

0

Small-scale

0.426

High

1268366

NU205
Nuclear pore complex protein Nup205

1

0

Small-scale

0.426

High

1300510

DBNL
Drebrin-like protein

1

0

Small-scale

0.426

High

801321

KI67
Proliferation marker protein Ki-67

1

1

Small-scale

0.407

High

1074212

SF3A1
Splicing factor 3A subunit 1

1

1

Small-scale

0.407

High

1127478

Q5JSD2
Voltage-dependent anion-selective channel protein 2

1

1

Small-scale

0.407

High

1259938

TB22A
TBC1 domain family member 22A

1

2

Small-scale

0.407

High

1152938

MRM1
rRNA methyltransferase 1, mitochondrial

3

0

High-throughput

0.347

High

941334

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

Small-scale

0.305

High

402369

JUN
Transcription factor Jun

2

0

High-throughput

0.298

High

875891

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

885385

LOXL3
Lysyl oxidase homolog 3

1

0

High-throughput

0.279

Low

1093036

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.279

Low

1173069

CF20D
Protein CFAP20DC

1

0

High-throughput

0.279

Low

1185624

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

1221985

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.279

Low

1298709

RUN3B
RUN domain-containing protein 3B

1

0

High-throughput

0.279

Low

1300481

C10
Protein C10

1

0

High-throughput

0.279

Low

1300484

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

1300511

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

1300516

ANR26
Ankyrin repeat domain-containing protein 26

1

0

High-throughput

0.279

Low

1300517

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

1300520

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

318702

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.249

Low

553485

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

652008

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721208

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

795783

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.249

Low

877841

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1062627

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

1080256

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1126670

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1171318

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1231308

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1236961

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1300492

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.249

Low

1300515

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

50222

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

Small-scale

0.232

Low

72106

B3KPW6
cDNA FLJ32365 fis, clone PUAEN1000161, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 1

1

0

Small-scale

0.232

Low

72921

B4DN50
Gap junction protein

1

0

Small-scale

0.232

Low

72930

B4DNC8
Large ribosomal subunit protein uL13

1

0

Small-scale

0.232

Low

81571

B7Z3B9
GRB2 associated binding protein 1

1

0

Small-scale

0.232

Low

81633

B7Z6D9
cDNA FLJ52750, highly similar to Rho guanine nucleotide exchange factor 7

1

0

Small-scale

0.232

Low

87317

C9J7X6
DENN domain-containing protein 11

1

0

Small-scale

0.232

Low

90099

D6RAY6
Centrosomal protein of 63 kDa

1

0

Small-scale

0.232

Low

90109

D6RDV0
Tumor suppressor candidate 3

1

0

Small-scale

0.232

Low

99501

F5H199
Peptide-methionine

1

0

Small-scale

0.232

Low

99837

F5H7Q6
Protein Wnt

1

0

Small-scale

0.232

Low

973981

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

Small-scale

0.232

Low

1166420

CLC4G
C-type lectin domain family 4 member G

1

0

Small-scale

0.232

Low

1236754

PCD20
Protocadherin-20

1

0

Small-scale

0.232

Low

1242765

TMM52
Transmembrane protein 52

1

0

Small-scale

0.232

Low

1260726

NAT14
Probable N-acetyltransferase 14

1

0

Small-scale

0.232

Low

1263160

NELFB
Negative elongation factor B

1

0

Small-scale

0.232

Low

1299324

RBM14
RNA-binding protein 14

1

0

Small-scale

0.232

Low

1300488

Z518B
Zinc finger protein 518B

1

0

Small-scale

0.232

Low

1300506

COMD3
COMM domain-containing protein 3

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024