Protein: INT6
Integrator complex subunit 6 (Int6) (DBI-1) (Protein deleted in cancer 1) (DICE1)

Gene: INT6, INTS6
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9UL03

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004888 - transmembrane signaling receptor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994415

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

5

5

Small-scale

0.927

High

977608

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

3

5

Small-scale

0.847

High

1450778

INT10
Integrator complex subunit 10

3

0

Small-scale

0.784

High

1229213

INT3
Integrator complex subunit 3

7

2

Small-scale

0.750

High

1403182

INT14
Integrator complex subunit 14

2

0

High-throughput

0.748

High

1450706

INT13
Integrator complex subunit 13

2

0

Small-scale

0.716

High

718042

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

4

3

Small-scale

0.697

High

158595

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

2

High-throughput

0.667

High

622008

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

1

Small-scale

0.656

High

723139

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

1

Small-scale

0.656

High

1409904

SOSB1
SOSS complex subunit B1

3

2

Small-scale

0.656

High

621792

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

Small-scale

0.651

High

1249456

OLFM4
Olfactomedin-4

3

0

High-throughput

0.638

High

1311538

BBS7
BBSome complex member BBS7

3

0

High-throughput

0.634

High

1243338

INT5
Integrator complex subunit 5

3

1

Small-scale

0.633

High

1260326

INT8
Integrator complex subunit 8

3

1

Small-scale

0.633

High

1410251

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

1

High-throughput

0.628

High

786923

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

Small-scale

0.618

High

968477

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.618

High

1206362

INT6L
Integrator complex subunit 6-like

1

3

High-throughput

0.618

High

667505

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

1

Small-scale

0.584

High

718195

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

3

Small-scale

0.584

High

1215023

INT11
Integrator complex subunit 11

2

1

Small-scale

0.584

High

1323857

INT1
Integrator complex subunit 1

2

2

Small-scale

0.584

High

1430050

INT2
Integrator complex subunit 2

2

1

Small-scale

0.584

High

1450310

INT9
Integrator complex subunit 9

2

1

Small-scale

0.584

High

1450527

INT7
Integrator complex subunit 7

2

1

Small-scale

0.584

High

397192

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

756403

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.569

High

1385767

INT12
Integrator complex subunit 12

2

0

Small-scale

0.559

High

1393587

INT4
Integrator complex subunit 4

2

0

Small-scale

0.559

High

954757

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.547

High

130654

SPT5H
Transcription elongation factor SPT5

1

4

High-throughput

0.536

High

407728

S100B
Protein S100-B

1

6

High-throughput

0.536

High

445286

S10A6
Protein S100-A6

1

6

High-throughput

0.536

High

682653

S100P
Protein S100-P

1

6

High-throughput

0.536

High

923565

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

959089

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.536

High

1065485

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1163279

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1368810

EZH1
Histone-lysine N-methyltransferase EZH1

1

1

High-throughput

0.536

High

1383215

SOSB2
SOSS complex subunit B2

1

2

High-throughput

0.536

High

542276

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

712303

TKT
Transketolase

1

0

High-throughput

0.513

High

913170

STAT2
Signal transducer and activator of transcription 2

1

0

High-throughput

0.513

High

948609

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1116124

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1404495

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1461343

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

Small-scale

0.501

High

595124

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.489

High

648801

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

1

High-throughput

0.489

High

706347

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

1331619

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

3

High-throughput

0.489

High

1461339

ANR50
Ankyrin repeat domain-containing protein 50

1

2

High-throughput

0.489

High

765990

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

775370

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

937964

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

1144595

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

1323546

ZN687
Zinc finger protein 687

1

1

High-throughput

0.479

High

1359723

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

1365472

ZN592
Zinc finger protein 592

1

1

High-throughput

0.479

High

1367561

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1461340

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

1

High-throughput

0.479

High

192882

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

194391

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

574511

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

590006

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696835

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714513

PML
Protein PML

1

0

High-throughput

0.458

High

769486

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

897618

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.458

High

905276

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

912155

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

912260

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

976177

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

980526

H4
Histone H4

1

0

High-throughput

0.458

High

983733

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1114627

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1229486

NAIF1
Nuclear apoptosis-inducing factor 1

1

0

High-throughput

0.458

High

1276949

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1370156

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

1398673

INT15
Integrator complex subunit 15

1

0

High-throughput

0.458

High

1437728

RENT2
Regulator of nonsense transcripts 2

1

0

Small-scale

0.458

High

1453042

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1459270

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

317382

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.445

High

355320

ACL6A
Actin-like protein 6A

1

1

High-throughput

0.445

High

1121914

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

Small-scale

0.445

High

1326142

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1414657

TCAB1
Telomerase Cajal body protein 1

1

2

High-throughput

0.445

High

1256047

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

50043

F170A
Protein FAM170A

1

0

High-throughput

0.426

High

143488

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

445616

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.426

High

1047138

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.426

High

1066808

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.426

High

1181450

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1251896

CCNI2
Cyclin-I2

1

0

High-throughput

0.426

High

1461341

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.426

High

1227683

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1231162

SCAR3
Scavenger receptor class A member 3

3

0

High-throughput

0.347

High

653745

PROZ
Vitamin K-dependent protein Z

3

0

High-throughput

0.345

High

1060932

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.328

High

169219

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

1216419

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1349412

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

0

High-throughput

0.279

Low

412791

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1256934

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1434205

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1211465

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.232

Low

1326489

S22AO
Steroid transmembrane transporter SLC22A24

1

0

High-throughput

0.232

Low

1420121

CHIA
Acidic mammalian chitinase

1

0

High-throughput

0.232

Low

1461338

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low

1461342

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025