HitPredict

Interactor 1: ITCH (Q8C863)
E3 ubiquitin-protein ligase Itchy (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Itchy homolog)
Gene: ITCH

Interactor 2: RNF11 (Q9QYK7)
RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669)
Gene: RNF11

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21765415
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 864 Mm			1 154
+	Hs
		1294890 ITCH_HUMAN (1-864): 0: 899: 91.27		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1240725 ITCH_HUMAN (1-864): 0: 899: 91.27		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		1255979 ITCH_HUMAN (1-864): 0: 899: 91.27		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		125810 WWP2_HUMAN (1-864): 0: 829: 56.01		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1327938 WWP1_HUMAN (1-864): 0: 828: 57.33		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1299666 NED4L_HUMAN (1-861): 0: 795: 32.68		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		125596 WWP2_HUMAN (1-864): 0: 829: 56.01		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1255980 NED4L_HUMAN (1-861): 0: 795: 32.68		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Mm
		808380 NEDD4_MOUSE (3-861): 0: 744: 32.18		RNF11_MOUSE (1-154): 1.27e-42: 140: 100.00
+	Hs
		808333 NEDD4_HUMAN (90-861): 0: 728: 35.88		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1192280 HUWE1_HUMAN (250-863): 1.38e-174: 562: 29.49		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1334883 SMUF2_HUMAN (1-353): 1.77e-44: 174: 21.41		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1336128 SMUF1_HUMAN (1-319): 3.8e-38: 155: 21.16		RNF11_HUMAN (1-154): 1.51e-42: 140: 99.35
+	Hs
		1334874 SMUF2_HUMAN (1-353): 1.77e-44: 174: 21.41		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29