HitPredict

Interactor 1: UBR4 (Q5T4S7)
E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600)
Gene: UBR4

Interactor 2: KCMF1 (Q9P0J7)
E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1)
Gene: KCMF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

The method score is based on:

Property	Details
Experiments	26186194, 25582440, 28514442, 29511261, 33961781, 34893540, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006979 - response to oxidative stress and 5 others more... GO:0008270 - zinc ion binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination GO:0141191 - negative regulation of HRI-mediated signaling
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	5183
Hs

1	381

Service provided by Combinatics, Japan

Last updated: 11Aug2025