HitPredict

Interactor 1: Q8IP45 (Q8IP45)
Cullin 3, isoform F (FI19425p1)
Gene: Cul3

Interactor 2: Q9VK21 (Q9VK21)
Kelch-like protein diablo
Gene: Ipp

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	17880263, 25242320
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 934 Dm			1 627
+	Dm
		1213843 Q8IP45_DROME (1-934): 0: 1150: 100.00		Q9VGE5_DROME (48-627): 1.44e-152: 453: 26.55
+	Dm
		1359793 Q9V475_DROME (174-934): 0: 924: 99.34		Q9VK21_DROME (1-627): 3.32e-169: 498: 100.00
+	Hs
		1041712 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH12_HUMAN (63-627): 3.31e-152: 452: 32.46
+	Hs
		299515 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH18_HUMAN (52-627): 2.24e-149: 445: 30.73
+	Hs
		1041807 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH10_HUMAN (47-627): 1.98e-146: 439: 26.93
+	Mm
		1322059 CUL3_MOUSE (171-934): 0: 909: 68.63		KLH10_MOUSE (47-627): 1.14e-145: 437: 26.76
+	Hs
		1041715 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH22_HUMAN (35-627): 5.74e-138: 418: 23.80
+	Hs
		1041718 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH26_HUMAN (44-627): 2.28e-134: 408: 23.99
+	Dm
		1213852 Q8IP45_DROME (1-934): 0: 1150: 100.00		KLHDB_DROME (253-477): 4.7e-34: 139: 23.56
+	Dm
		980063 Q8IP45_DROME (1-934): 0: 1150: 100.00		KELC_DROME (296-482): 2.2e-31: 133: 22.87
+	Dm
		1151465 Q8IP45_DROME (1-934): 0: 1150: 100.00		Q6GKZ1_DROME (327-431): 3.95e-13: 74.7: 20.95
+	Hs
		152489 CUL3_HUMAN (171-934): 0: 909: 68.50		ENC1_HUMAN (50-618): 8.28e-70: 238: 29.51
+	Hs
		1041547 CUL3_HUMAN (171-934): 0: 909: 68.50		KEAP1_HUMAN (429-627): 5.4e-46: 174: 28.71
+	Mm
		1337550 CUL3_MOUSE (171-934): 0: 909: 68.63		KEAP1_MOUSE (429-627): 7.31e-46: 173: 29.21
+	Hs
		307170 CUL3_HUMAN (171-934): 0: 909: 68.50		KLHL2_HUMAN (296-478): 2.64e-32: 133: 27.17
+	Mm
		1225041 CUL3_MOUSE (171-934): 0: 909: 68.63		KLHL2_MOUSE (296-478): 6.01e-32: 132: 27.17
+	Hs
		1041852 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH17_HUMAN (308-477): 1.32e-29: 126: 30.00
+	Rn
		78189 CUL3_RAT (171-934): 0: 910: 68.63		KLH17_RAT (308-477): 2.23e-29: 125: 30.00
+	Hs
		1041853 CUL3_HUMAN (171-934): 0: 909: 68.50		KLH24_HUMAN (206-478): 3.57e-20: 96.5: 16.42
+	Dm
		1151468 Q9V475_DROME (174-934): 0: 924: 99.34		Q6GKZ1_DROME (327-431): 3.95e-13: 74.7: 20.95