Protein: MCES
mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)

Gene: MCES, RNMT
Organism: Homo sapiens
Interactions: 50
UniProt ID: O43148

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0004482 - mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

195653

RAMAC
RNA guanine-N7 methyltransferase activating subunit

5

0

High-throughput

0.881

High

195612

IMA7
Importin subunit alpha-7

5

5

High-throughput

0.721

High

195633

IMA5
Importin subunit alpha-5

4

5

High-throughput

0.704

High

195632

IMA1
Importin subunit alpha-1

3

5

High-throughput

0.665

High

168601

IMA6
Importin subunit alpha-6

2

5

High-throughput

0.628

High

195618

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

195651

GMCL1
Germ cell-less protein-like 1

2

0

High-throughput

0.580

High

134804

IMA3
Importin subunit alpha-3

1

5

High-throughput

0.536

High

195637

CUL1
Cullin-1

1

3

High-throughput

0.536

High

195638

CUL2
Cullin-2

1

3

High-throughput

0.536

High

195639

CUL3
Cullin-3

1

3

High-throughput

0.536

High

195649

CUL5
Cullin-5

1

3

High-throughput

0.536

High

195626

EGLN
Endoglin

1

0

High-throughput

0.513

High

195641

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

195645

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

195648

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

195650

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

195614

MCE1
mRNA-capping enzyme

1

1

Small-scale

0.501

High

195619

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

195622

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

195628

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

195636

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

195640

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

195611

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

195613

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

195615

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

195617

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

195620

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

195624

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

195625

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

195627

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

Small-scale

0.458

High

195629

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

195630

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

195631

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

195634

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

195635

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

195644

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

195647

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.458

High

195652

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

195658

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

195623

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

195621

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

195646

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.328

High

195656

PKHA3
Pleckstrin homology domain-containing family A member 3

2

0

High-throughput

0.316

High

195642

H90B4
Putative heat shock protein HSP 90-beta 4

2

0

High-throughput

0.288

High

195643

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

195654

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

195655

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

195657

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

195616

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024