Protein: NIPBL
Nipped-B-like protein (Delangin) (SCC2 homolog)

Gene: NIPBL
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q6KC79

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001656 - metanephros development
GO:0003007 - heart morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1130076

SMC1A
Structural maintenance of chromosomes protein 1A

3

20

Small-scale

0.847

High

1235693

SMC3
Structural maintenance of chromosomes protein 3

3

16

Small-scale

0.827

High

1235702

SCC4
MAU2 chromatid cohesion factor homolog

6

1

Small-scale

0.736

High

1097353

CBX3
Chromobox protein homolog 3

4

8

Small-scale

0.680

High

853302

CBX5
Chromobox protein homolog 5

2

8

Small-scale

0.636

High

1235653

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

2

High-throughput

0.628

High

1235652

STAG2
Cohesin subunit SA-2

2

4

High-throughput

0.611

High

911274

IMA5
Importin subunit alpha-5

2

5

High-throughput

0.601

High

260085

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

588929

RFA2
Replication protein A 32 kDa subunit

2

7

High-throughput

0.584

High

656156

PPIB
Peptidyl-prolyl cis-trans isomerase B

2

10

High-throughput

0.584

High

695717

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

7

High-throughput

0.584

High

768433

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

872435

SOX2
Transcription factor SOX-2

2

17

Small-scale

0.584

High

998438

H31
Histone H3.1

2

19

High-throughput

0.584

High

1133469

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

396322

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

551102

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.561

High

1025368

CDK6
Cyclin-dependent kinase 6

1

15

Small-scale

0.550

High

340162

PCNT
Pericentrin

1

20

High-throughput

0.541

High

179057

IMA6
Importin subunit alpha-6

1

5

High-throughput

0.536

High

542070

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

634489

LMNB1
Lamin-B1

1

11

High-throughput

0.536

High

693795

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

854111

KI67
Proliferation marker protein Ki-67

1

18

High-throughput

0.536

High

867212

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.536

High

1013071

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.536

High

1014130

CBX1
Chromobox protein homolog 1

1

8

High-throughput

0.536

High

1062509

DHX9
ATP-dependent RNA helicase A

1

6

High-throughput

0.536

High

1065244

SSRP1
FACT complex subunit SSRP1

1

12

High-throughput

0.536

High

1162989

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1235664

TFG
Protein TFG

1

14

High-throughput

0.536

High

1235671

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

520133

ANDR
Androgen receptor

1

20

High-throughput

0.534

High

326255

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

1141173

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.515

High

659245

SP100
Nuclear autoantigen Sp-100

1

14

Small-scale

0.501

High

964330

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

1235676

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

20

High-throughput

0.501

High

1235647

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1235691

AT7L1
Ataxin-7-like protein 1

1

10

High-throughput

0.489

High

1235673

HINFP
Histone H4 transcription factor

1

3

Small-scale

0.481

High

130510

SPT5H
Transcription elongation factor SPT5

1

11

High-throughput

0.479

High

143052

NFIB
Nuclear factor 1 B-type

1

10

High-throughput

0.479

High

157501

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.479

High

162607

ANM5
Protein arginine N-methyltransferase 5

1

2

High-throughput

0.479

High

176073

KDM6B
Lysine-specific demethylase 6B

1

19

Small-scale

0.479

High

181524

TBXT
T-box transcription factor T

1

5

High-throughput

0.479

High

190956

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

210023

CRX
Cone-rod homeobox protein

1

12

High-throughput

0.479

High

225028

TLX3
T-cell leukemia homeobox protein 3

1

10

High-throughput

0.479

High

226560

TLX2
T-cell leukemia homeobox protein 2

1

6

High-throughput

0.479

High

272260

OBSL1
Obscurin-like protein 1

1

18

High-throughput

0.479

High

285333

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

285963

SF3B1
Splicing factor 3B subunit 1

1

6

High-throughput

0.479

High

289579

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

8

High-throughput

0.479

High

339778

KLF8
Krueppel-like factor 8

1

16

High-throughput

0.479

High

340901

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.479

High

345949

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

19

High-throughput

0.479

High

372302

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

385852

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.479

High

404132

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

408935

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

456759

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

461594

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.479

High

474061

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.479

High

487433

PARP1
Poly [ADP-ribose] polymerase 1

1

13

High-throughput

0.479

High

519391

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

537349

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

538414

EGR2
E3 SUMO-protein ligase EGR2

1

2

High-throughput

0.479

High

540888

ERG
Transcriptional regulator ERG

1

9

High-throughput

0.479

High

581669

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

591688

H2AX
Histone H2AX

1

9

High-throughput

0.479

High

637572

FLNA
Filamin-A

1

20

High-throughput

0.479

High

662443

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

685230

PAX6
Paired box protein Pax-6

1

7

High-throughput

0.479

High

697149

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

703156

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

725267

TLX1
T-cell leukemia homeobox protein 1

1

11

High-throughput

0.479

High

729313

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

10

High-throughput

0.479

High

775859

HNF1B
Hepatocyte nuclear factor 1-beta

1

11

High-throughput

0.479

High

799211

BRCA1
Breast cancer type 1 susceptibility protein

1

13

High-throughput

0.479

High

833969

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

839897

AF9
Protein AF-9

1

6

Small-scale

0.479

High

879190

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

883582

CENPA
Histone H3-like centromeric protein A

1

19

High-throughput

0.479

High

886954

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.479

High

904837

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

910315

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

2

High-throughput

0.479

High

920043

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

937275

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

19

High-throughput

0.479

High

938459

PAX9
Paired box protein Pax-9

1

7

High-throughput

0.479

High

944683

KLF3
Krueppel-like factor 3

1

17

High-throughput

0.479

High

964642

DCAF7
DDB1- and CUL4-associated factor 7

1

16

High-throughput

0.479

High

965732

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

13

High-throughput

0.479

High

979834

H4
Histone H4

1

10

High-throughput

0.479

High

980847

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

996207

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

1016949

H33
Histone H3.3

1

19

High-throughput

0.479

High

1023094

RBM10
RNA-binding protein 10

1

7

High-throughput

0.479

High

1033025

EWS
RNA-binding protein EWS

1

10

High-throughput

0.479

High

1048004

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

1052877

HME1
Homeobox protein engrailed-1

1

5

High-throughput

0.479

High

1053373

CTSL2
CTD small phosphatase-like protein 2

1

4

Small-scale

0.479

High

1056615

PAX8
Paired box protein Pax-8

1

8

High-throughput

0.479

High

1087804

NFIA
Nuclear factor 1 A-type

1

18

High-throughput

0.479

High

1100013

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

1107829

SQSTM
Sequestosome-1

1

8

High-throughput

0.479

High

1108567

TBB3
Tubulin beta-3 chain

1

6

High-throughput

0.479

High

1111047

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.479

High

1118720

KLF5
Krueppel-like factor 5

1

16

High-throughput

0.479

High

1119828

CKAP5
Cytoskeleton-associated protein 5

1

6

High-throughput

0.479

High

1138311

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1141693

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

1144275

STK38
Serine/threonine-protein kinase 38

1

18

High-throughput

0.479

High

1144374

NONO
Non-POU domain-containing octamer-binding protein

1

12

High-throughput

0.479

High

1145810

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

1146923

PCBP2
Poly(rC)-binding protein 2

1

12

High-throughput

0.479

High

1147915

SF3B3
Splicing factor 3B subunit 3

1

6

High-throughput

0.479

High

1160834

NFIL3
Nuclear factor interleukin-3-regulated protein

1

9

High-throughput

0.479

High

1191840

TBB8
Tubulin beta-8 chain

1

6

High-throughput

0.479

High

1235244

ANO7
Anoctamin-7

1

1

Small-scale

0.479

High

1235637

NIPBL
Nipped-B-like protein

1

13

High-throughput

0.479

High

1235640

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

1235641

SETX
Probable helicase senataxin

1

2

High-throughput

0.479

High

1235642

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1235644

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

7

Small-scale

0.479

High

1235646

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1235648

MGAP
MAX gene-associated protein

1

7

High-throughput

0.479

High

1235649

SMC5
Structural maintenance of chromosomes protein 5

1

18

High-throughput

0.479

High

1235650

SLX4
Structure-specific endonuclease subunit SLX4

1

19

High-throughput

0.479

High

1235654

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1235655

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.479

High

1235656

SP7
Transcription factor Sp7

1

15

High-throughput

0.479

High

1235658

PNISR
Arginine/serine-rich protein PNISR

1

8

High-throughput

0.479

High

1235659

ZFP90
Zinc finger protein 90 homolog

1

1

High-throughput

0.479

High

1235660

STAG1
Cohesin subunit SA-1

1

4

High-throughput

0.479

High

1235662

PHF3
PHD finger protein 3

1

5

High-throughput

0.479

High

1235663

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1235665

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

High-throughput

0.479

High

1235666

FUBP2
Far upstream element-binding protein 2

1

12

High-throughput

0.479

High

1235667

MED12
Mediator of RNA polymerase II transcription subunit 12

1

15

High-throughput

0.479

High

1235668

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1235672

FEV
Protein FEV

1

8

High-throughput

0.479

High

1235675

KLF16
Krueppel-like factor 16

1

13

High-throughput

0.479

High

1235677

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

1235678

PDIP3
Polymerase delta-interacting protein 3

1

5

High-throughput

0.479

High

1235679

DDX47
Probable ATP-dependent RNA helicase DDX47

1

10

High-throughput

0.479

High

1235680

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1235684

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

12

High-throughput

0.479

High

1235685

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1235686

LHX3
LIM/homeobox protein Lhx3

1

8

High-throughput

0.479

High

1235688

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1235689

MED13
Mediator of RNA polymerase II transcription subunit 13

1

2

High-throughput

0.479

High

1235690

KLF15
Krueppel-like factor 15

1

15

High-throughput

0.479

High

1235692

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

Small-scale

0.479

High

1235694

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1235695

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

1235696

ST38L
Serine/threonine-protein kinase 38-like

1

16

High-throughput

0.479

High

1235697

TR150
Thyroid hormone receptor-associated protein 3

1

20

High-throughput

0.479

High

1235699

PKP3
Plakophilin-3

1

14

High-throughput

0.479

High

1235701

SNX9
Sorting nexin-9

1

1

High-throughput

0.479

High

229031

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

671807

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

799937

COIL
Coilin

1

0

High-throughput

0.458

High

869286

XDH
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

1

0

High-throughput

0.458

High

1213746

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1235638

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

1235643

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1235657

PANK1
Pantothenate kinase 1

1

0

High-throughput

0.458

High

1235661

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

1235670

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.458

High

1235674

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

High-throughput

0.458

High

1235698

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1235669

CEP63
Centrosomal protein of 63 kDa

1

16

High-throughput

0.457

High

881544

CDK8
Cyclin-dependent kinase 8

1

20

Small-scale

0.445

High

787037

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

8

High-throughput

0.437

High

1041668

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

2

Small-scale

0.437

High

1235639

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

1235681

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1235683

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

High-throughput

0.426

High

947011

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

1160660

DREB
Drebrin

1

10

High-throughput

0.417

High

166323

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.407

High

477337

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

1216367

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1231978

IL31
Interleukin-31

1

0

High-throughput

0.279

Low

1235687

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.279

Low

1235700

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

1235651

IQCK
IQ domain-containing protein K

1

0

High-throughput

0.249

Low

1235682

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.249

Low

1235645

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025