HitPredict

Interactor 1: LUBEL (Q8IPJ3)
E3 ubiquitin-protein ligase lubel (EC 2.3.2.31) (Linear Ubiquitin E3 ligase)
Gene: LUBEL

Interactor 2: Q9W418 (Q9W418)
GH17761p (Ubiquitin-5E, isoform A) (Ubiquitin-5E, isoform B)
Gene: Ubi-p5E

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.80	0.648

Property	Details
Experiments	27702987
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~ubiquitin, IBR~ubiquitin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2892 Dm			1 534
+	Dm
		477528 LUBEL_DROME (1-2892): 0: 1205: 100.00		UBIQP_DROME (1-458): 0: 566: 99.78
+	Hs
		476630 ARI1_HUMAN (2419-2885): 2.33e-133: 433: 18.33		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476187 RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		312458 ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Mm
		476959 RNF31_MOUSE (2258-2889): 2.63e-132: 447: 28.28		UBC_MOUSE (1-108): 3.81e-30: 127: 90.74
+	Hs
		475133 RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		312457 ARI2_HUMAN (2370-2864): 2.52e-124: 404: 14.80		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		475976 R144B_HUMAN (2496-2754): 5.25e-77: 260: 19.40		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476496 AKIB1_HUMAN (2408-2881): 1.8e-68: 256: 14.41		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		475494 R144A_HUMAN (2510-2754): 1.5e-72: 247: 20.47		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		475094 CUL9_HUMAN (2385-2869): 4.96e-89: 328: 15.74		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		475939 RN19B_HUMAN (2509-2765): 2.33e-65: 240: 21.85		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		226335 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Sc
		477225 HEL1_YEAST (2418-2837): 2.1e-88: 302: 14.79		UBI4P_YEAST (1-77): 3.08e-23: 103: 94.81
+	Rn
		1144287 PRKN_RAT (2340-2728): 5.15e-70: 246: 15.68		UBC_RAT (1-108): 3.8e-30: 127: 90.74
+	Mm
		476729 RN216_MOUSE (1981-2741): 9.82e-66: 244: 15.64		UBC_MOUSE (1-108): 3.81e-30: 127: 90.74
+	Hs
		475069 RN19B_HUMAN (2509-2765): 2.33e-65: 240: 21.85		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		226334 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		171468 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		UBD_HUMAN (231-374): 3.14e-21: 92.4: 31.33
+	Hs
		226251 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		ISG15_HUMAN (307-456): 2.08e-17: 81.6: 32.68