HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 500 Hs			1 732
+	Hs
		438082 ANK2_HUMAN (162-497): 6.94e-75: 259: 19.01		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438117 ANK3_HUMAN (1-346): 2.28e-58: 211: 14.37		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Dr
		223349 MIB1_DANRE (272-500): 2.6e-40: 157: 21.74		HS90B_DANRE (19-732): 0: 1063: 86.73
+	Hs
		432398 ASB3_HUMAN (199-468): 5.42e-32: 130: 16.55		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432073 ANKK1_HUMAN (1-330): 1.67e-29: 124: 10.00		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431882 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438653 ASB3_HUMAN (199-468): 5.42e-32: 130: 16.55		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431682 DAPK1_HUMAN (4-284): 1.05e-20: 97.9: 10.68		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438365 ANKK1_HUMAN (1-330): 1.67e-29: 124: 10.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431704 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438197 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		432263 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432186 Q96T11_HUMAN (403-500): 3.4e-14: 77.1: 23.47		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		438529 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		121560 IKBE_HUMAN (405-499): 6.48e-15: 79.1: 22.86		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437883 NFKB1_HUMAN (386-481): 8.64e-13: 72.8: 24.51		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		538174 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		538399 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		587599 NFKB1_HUMAN (386-481): 8.64e-13: 72.8: 24.51		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		1123425 ANKK1_HUMAN (1-330): 1.67e-29: 124: 10.00		H90B4_HUMAN (30-604): 0: 571: 62.61