HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 500 Hs			1 542
+	Mm
		222603 IKBE_MOUSE (140-500): 7.25e-73: 237: 80.82		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Hs
		1076395 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		862124 DAPK1_HUMAN (4-284): 1.05e-20: 97.9: 10.68		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		883666 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1330876 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1302644 Q96T11_HUMAN (403-500): 3.4e-14: 77.1: 23.47		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		587745 NFKB1_HUMAN (386-481): 8.64e-13: 72.8: 24.51		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1076397 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Mm
		1112906 IKBB_MOUSE (226-441): 4.25e-26: 110: 37.21		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Mm
		1112931 NFKB2_MOUSE (343-498): 9.78e-22: 100: 23.39		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Hs
		883676 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1330889 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		121606 IKBE_HUMAN (405-499): 6.48e-15: 79.1: 22.86		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		72802 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		B4DH70_HUMAN (40-542): 5.29e-155: 454: 98.41
+	Hs
		1302645 Q96T11_HUMAN (403-500): 3.4e-14: 77.1: 23.47		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		166894 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		LIS1_HUMAN (276-542): 4.94e-75: 245: 28.43
+	Hs
		587665 NFKB1_HUMAN (386-481): 8.64e-13: 72.8: 24.51		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		121550 IKBE_HUMAN (405-499): 6.48e-15: 79.1: 22.86		PRP4_HUMAN (320-536): 4.83e-42: 159: 22.13
+	Hs
		883544 RIPK4_HUMAN (381-500): 5.47e-16: 82.9: 21.67		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		1163035 Q9H4D1_HUMAN (403-500): 4.98e-15: 79.8: 23.47		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17