HitPredict

Interactor 1: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.980

The method score is based on:

Property Details
Experiments 25416956, 21248071, 32479599, 9582267, 11752454, 17420721, 19224863, 12421809, 23027902, 22493164, 21988832, 24316825, 20940148
Identification Methods two hybrid, affinity chromatography technology, pull down, biochemical, enzymatic study, x-ray crystallography, two hybrid array
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Sina~Sina
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
and 18 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 282
Hs

1 282
+ Mm
+ Hs
+ Dm
+ Hs
+ At
+ At
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024