HitPredict

Interactor 1: PSD11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
Gene: PSMD11

Interactor 2: CSN2 (P61201)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: COPS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PCI~PCI
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 422 Hs			1 443
+	Dm
		1180707 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		CSN2_DROME (16-443): 5.59e-115: 345: 83.92
+	Hs
		897224 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00
+	Hs
		121628 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSD11_HUMAN (35-442): 5.44e-89: 278: 22.43
+	Hs
		121764 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01
+	Dm
		1277029 CSN2_DROME (8-419): 1.91e-87: 274: 20.90		CSN2_DROME (16-443): 5.59e-115: 345: 83.92
+	Hs
		121629 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80
+	Dm
		1180710 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSMD6_DROME (58-439): 1.55e-80: 255: 12.89
+	Zm
		6700 A0A1D6E9U1_MAIZE (6-421): 8.13e-98: 300: 50.48		A0A1D6E9U1_MAIZE (39-443): 8.71e-87: 273: 22.17
+	Dm
		1180709 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		CSN4_DROME (52-440): 4.52e-70: 229: 15.42
+	At
		1338954 PSD11_ARATH (10-421): 4.55e-96: 295: 51.94		PSD11_ARATH (42-443): 2.17e-80: 256: 22.98
+	Mm
		102346 CSN2_MOUSE (8-419): 1.5e-88: 277: 22.80		G3UXW9_MOUSE (17-443): 1.81e-80: 259: 15.39
+	Hs
		897237 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02
+	Hs
		897302 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25
+	Mm
		291856 CSN2_MOUSE (8-419): 1.5e-88: 277: 22.80		CSN4_MOUSE (54-440): 4.16e-70: 229: 16.29
+	Dm
		1277030 CSN2_DROME (8-419): 1.91e-87: 274: 20.90		CSN4_DROME (52-440): 4.52e-70: 229: 15.42
+	Sc
		1015535 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		RPN6_YEAST (67-443): 8.69e-76: 245: 21.43
+	At
		1226050 CSN2_ARATH (8-418): 1.68e-84: 267: 18.96		CSN4_ARATH (73-439): 8.3e-58: 196: 15.21
+	At
		799481 PSD11_ARATH (10-421): 4.55e-96: 295: 51.94		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15
+	At
		799473 CSN2_ARATH (8-418): 1.68e-84: 267: 18.96		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15