HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26186194, 35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 264
+	Hs
		121942 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69
+	Hs
		121892 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16
+	Hs
		121936 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23
+	Hs
		121979 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69
+	Hs
		122073 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23
+	Hs
		121945 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07
+	Hs
		121930 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB1_HUMAN (26-246): 7.33e-70: 217: 22.61
+	Zm
		80010 C0P4D6_MAIZE (35-454): 1.47e-133: 394: 42.66		B6TAJ3_MAIZE (30-262): 6.44e-74: 228: 13.28
+	Sc
		675493 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB7_YEAST (41-263): 9.78e-92: 273: 42.92
+	Sc
		675446 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB5_YEAST (17-264): 4.06e-81: 247: 23.44
+	Sc
		689218 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSA5_YEAST (26-264): 8.42e-74: 227: 15.69
+	Sc
		625964 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB2_YEAST (46-263): 2.87e-67: 210: 19.09
+	Hs
		121690 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00
+	Hs
		893638 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69
+	Hs
		121689 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69
+	Hs
		121635 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16
+	Hs
		121684 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23
+	Hs
		121719 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69
+	Hs
		121692 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07
+	Hs
		121678 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB1_HUMAN (26-246): 7.33e-70: 217: 22.61