HitPredict

Interactor 1: UBR1 (Q8IWV7)
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)
Gene: UBR1

Interactor 2: UBE2Z (Q9H832)
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)
Gene: UBE2Z

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21816346
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1749 Hs			1 354
+	Hs
		919779 UBR1_HUMAN (1-1749): 0: 2525: 100.00		UB2D2_HUMAN (99-253): 3.54e-72: 222: 34.40
+	Hs
		849365 UBR1_HUMAN (1-1749): 0: 2525: 100.00		UB2D1_HUMAN (99-253): 2.91e-71: 220: 31.85
+	Hs
		1219647 UBR2_HUMAN (21-1749): 0: 2327: 47.00		UBE2Z_HUMAN (1-354): 2.59e-111: 330: 100.00
+	Hs
		919780 UBR2_HUMAN (21-1749): 0: 2327: 47.00		UB2D2_HUMAN (99-253): 3.54e-72: 222: 34.40
+	Hs
		1219640 UBR2_HUMAN (21-1749): 0: 2327: 47.00		UBE2O_HUMAN (104-242): 7.06e-21: 96.3: 40.14
+	Hs
		1170453 UBR3_HUMAN (986-1726): 8.48e-85: 311: 20.67		UBE2Z_HUMAN (1-354): 2.59e-111: 330: 100.00
+	Hs
		919760 UBR3_HUMAN (986-1726): 8.48e-85: 311: 20.67		UB2D2_HUMAN (99-253): 3.54e-72: 222: 34.40
+	Pf
		1211734 Q8I586_PLAF7 (317-529): 2.22e-11: 71.7: 22.90		Q8IAW2_PLAF7 (103-230): 1.74e-18: 83.2: 37.50