HitPredict

Interactor 1: NPAS3 (Q8IXF0)
Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6)
Gene: NPAS3

Interactor 2: X5D7T2 (X5D7T2)
Aryl-hydrocarbon receptor nuclear translocator 2 isoform C
Gene: ARNT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 933 Hs			1 694
+	Hs
		1220557 NPAS3_HUMAN (1-933): 0: 941: 100.00		ARNT2_HUMAN (1-685): 0: 671: 99.85
+	Hs
		1378460 X5D985_HUMAN (33-933): 0: 897: 98.34		X5D7T2_HUMAN (1-694): 0: 680: 100.00
+	Hs
		1378461 X5DR67_HUMAN (1-933): 0: 893: 94.30		X5D7T2_HUMAN (1-694): 0: 680: 100.00
+	Hs
		1220559 NPAS3_HUMAN (1-933): 0: 941: 100.00		X5DP31_HUMAN (1-621): 0: 627: 94.21
+	Hs
		1335644 X5D985_HUMAN (33-933): 0: 897: 98.34		ARNT2_HUMAN (1-685): 0: 671: 99.85
+	Hs
		1335647 X5DR67_HUMAN (1-933): 0: 893: 94.30		ARNT2_HUMAN (1-685): 0: 671: 99.85
+	Hs
		1378465 X5D985_HUMAN (33-933): 0: 897: 98.34		X5DP31_HUMAN (1-621): 0: 627: 94.21
+	Hs
		649132 NPAS3_HUMAN (1-933): 0: 941: 100.00		ARNT_HUMAN (5-672): 3.33e-176: 524: 56.00
+	Mm
		101520 F8VQB2_MOUSE (4-933): 0: 904: 93.55		ARNT_MOUSE (5-686): 2.48e-176: 524: 55.90
+	Hs
		1085690 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		HIF1A_HUMAN (48-634): 7.65e-135: 418: 21.66
+	Hs
		1085741 X5DP31_HUMAN (1-653): 3.27e-148: 455: 18.99		HIF1A_HUMAN (48-634): 7.65e-135: 418: 21.66
+	Hs
		1306541 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		EPAS1_HUMAN (50-693): 7.27e-131: 409: 18.75
+	Hs
		1050587 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		SIM2_HUMAN (65-680): 1.67e-132: 407: 19.61
+	Hs
		946354 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		SIM1_HUMAN (65-683): 2.39e-131: 407: 20.69
+	Hs
		1306157 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		NPAS1_HUMAN (27-631): 1.25e-106: 338: 16.77
+	Hs
		728962 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		AHR_HUMAN (68-580): 7.78e-101: 330: 16.57
+	Hs
		1306192 ARNT2_HUMAN (1-722): 2.44e-147: 455: 17.82		NPAS2_HUMAN (56-691): 1.96e-95: 314: 18.74