Protein: RN213
E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)

Gene: RN213, RNF213
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q63HN8

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002040 - sprouting angiogenesis
GO:0002376 - immune system process
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1224731

RN213
E3 ubiquitin-protein ligase RNF213

3

1

Small-scale

0.835

High

508126

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

0

Small-scale

0.791

High

995977

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

2

Small-scale

0.778

High

783297

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.773

High

425538

ISG15
Ubiquitin-like protein ISG15

1

1

Small-scale

0.724

High

957758

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.713

High

572021

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.702

High

1147175

ELOB
Elongin-B

1

0

High-throughput

0.656

High

957099

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

2

Small-scale

0.647

High

957608

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

3

Small-scale

0.647

High

982210

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

High-throughput

0.647

High

611171

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

0

High-throughput

0.638

High

1218717

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

Small-scale

0.621

High

174529

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.618

High

714190

PML
Protein PML

1

1

High-throughput

0.618

High

957416

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.618

High

1162673

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

3

Small-scale

0.618

High

1224740

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.618

High

520878

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

1

High-throughput

0.611

High

1224739

DLK2
Protein delta homolog 2

2

0

High-throughput

0.602

High

1224752

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

638442

FPR1
fMet-Leu-Phe receptor

2

2

High-throughput

0.601

High

241973

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.586

High

1224741

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

2

0

High-throughput

0.576

High

1224746

OSTM1
Osteopetrosis-associated transmembrane protein 1

2

0

High-throughput

0.576

High

1224791

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

0

High-throughput

0.576

High

1048881

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

1151537

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.549

High

1211740

UBX11
UBX domain-containing protein 11

1

0

High-throughput

0.549

High

1224734

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.549

High

1224750

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

359672

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

Small-scale

0.537

High

182579

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

774409

BASI
Basigin

1

1

High-throughput

0.536

High

867971

GLR
Glucagon receptor

1

1

High-throughput

0.536

High

1022874

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

1122255

SCRIB
Protein scribble homolog

1

1

High-throughput

0.536

High

1063330

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

71214

HIDE1
Protein HIDE1

1

0

High-throughput

0.513

High

158231

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

291812

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

385841

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

486571

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

673896

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.513

High

923705

SMTN
Smoothelin

1

0

High-throughput

0.513

High

974580

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1134464

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.513

High

1224748

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

1224749

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1224751

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1224755

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1224762

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.513

High

1224771

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

0

High-throughput

0.513

High

1224784

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

1224795

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

830906

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

165956

FFAR1
Free fatty acid receptor 1

1

1

High-throughput

0.489

High

640399

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

683256

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.489

High

1132199

CBX2
Chromobox protein homolog 2

1

2

High-throughput

0.489

High

1224797

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

465548

IGF1R
Insulin-like growth factor 1 receptor

1

0

High-throughput

0.479

High

62024

LRRD1
Leucine-rich repeat and death domain-containing protein 1

1

1

High-throughput

0.479

High

363410

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

464166

TPM2
Tropomyosin beta chain

1

1

High-throughput

0.479

High

469100

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.479

High

520125

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

610008

VGFR1
Vascular endothelial growth factor receptor 1

1

1

High-throughput

0.479

High

787035

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

High-throughput

0.479

High

983505

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

High-throughput

0.479

High

984156

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

1113366

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1114886

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1220558

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1224754

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

1224758

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1224792

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

High-throughput

0.479

High

129174

MEN1
Menin

1

0

High-throughput

0.458

High

157493

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

420569

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

695690

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

888125

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

965724

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

Small-scale

0.458

High

978996

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1128408

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

Small-scale

0.458

High

1140408

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1144367

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.458

High

1161490

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1224733

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1224744

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1224760

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1224763

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1224764

MCRS1
Microspherule protein 1

1

0

High-throughput

0.458

High

1224765

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1224769

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1224774

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1224775

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1224779

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1224782

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1224783

LYAR
Cell growth-regulating nucleolar protein

1

0

Small-scale

0.458

High

1224786

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1224787

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1224793

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1224794

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

253161

MOT2
Monocarboxylate transporter 2

1

1

High-throughput

0.445

High

380063

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

1224732

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

1224735

Q6IAX9
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.445

High

1224737

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.445

High

1224738

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.445

High

1224742

MOT13
Monocarboxylate transporter 13

1

1

High-throughput

0.445

High

1224777

Q9H932
cDNA FLJ13051 fis, clone NT2RP3001447

1

1

High-throughput

0.445

High

1224789

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

129745

CBX4
E3 SUMO-protein ligase CBX4

1

2

High-throughput

0.437

High

338868

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.437

High

887432

CEBPD
CCAAT/enhancer-binding protein delta

1

1

High-throughput

0.437

High

1224770

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.437

High

50579

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

166320

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

212422

SPIT2
Kunitz-type protease inhibitor 2

1

0

High-throughput

0.426

High

457496

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

538766

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.426

High

563898

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1199514

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1224736

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.426

High

1224753

DNJB8
DnaJ homolog subfamily B member 8

1

0

High-throughput

0.426

High

1224768

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

72951

B1AKQ8
G protein subunit beta 1

1

2

High-throughput

0.407

High

835293

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.407

High

914428

EFNB2
Ephrin-B2

1

1

High-throughput

0.407

High

1010928

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

1215996

Q5TCU3
Tropomyosin 2

1

1

High-throughput

0.407

High

1224761

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1224766

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.407

High

262245

SCN2B
Sodium channel regulatory subunit beta-2

4

0

High-throughput

0.360

High

1224772

CD244
Natural killer cell receptor 2B4

4

0

High-throughput

0.360

High

760450

SDC2
Syndecan-2

2

0

High-throughput

0.328

High

1224790

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

139232

UPK2
Uroplakin-2

2

0

High-throughput

0.313

High

1101518

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

0

High-throughput

0.313

High

1224778

TMM9B
Transmembrane protein 9B

2

0

High-throughput

0.313

High

1206598

PLAC9
Placenta-specific protein 9

1

0

High-throughput

0.282

High

137069

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.279

Low

1159202

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1178999

S35G1
Solute carrier family 35 member G1

1

0

High-throughput

0.279

Low

1215553

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.279

Low

1224745

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.279

Low

1224747

CPNE8
Copine-8

1

0

High-throughput

0.279

Low

1224756

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1224767

OPALI
Opalin

1

0

High-throughput

0.279

Low

1224773

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1224780

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.279

Low

1224785

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1224788

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low

1224796

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1037197

H11
Histone H1.1

1

0

High-throughput

0.269

Low

964324

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.261

Low

218309

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

260076

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

318805

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

588905

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

768408

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1224759

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

379527

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

516846

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

653376

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1219490

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1224743

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1224757

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.232

Low

1224776

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.232

Low

1224781

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025