HitPredict

Interactor 1: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Interactor 2: ATAD5 (Q96QE3)
ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
Gene: ATAD5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36373674
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1101 Hs			1 1844
+	Hs
		1154049 SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00		NIPBL_HUMAN (66-837): 6.64e-54: 211: 12.10
+	Hs
		722261 SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		1221669 SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00		MINT_HUMAN (11-1047): 1.47e-21: 105: 9.24
+	Hs
		1056884 SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Hs
		1154087 SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91		NIPBL_HUMAN (66-837): 6.64e-54: 211: 12.10
+	Mm
		1154102 SMC3_MOUSE (51-1061): 1.42e-81: 292: 13.91		NIPBL_MOUSE (66-837): 5.14e-51: 202: 12.74
+	Hs
		802457 SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00		ATRX_HUMAN (88-1036): 2.62e-11: 71.5: 13.08
+	Hs
		802521 SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91		ATRX_HUMAN (88-1036): 2.62e-11: 71.5: 13.08
+	Hs
		1056947 SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Hs
		311499 SMC2_HUMAN (51-1055): 9.8e-55: 210: 11.41		ATRX_HUMAN (88-1036): 2.62e-11: 71.5: 13.08
+	Hs
		725139 MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60		ANK2_HUMAN (9-821): 4.41e-12: 73.8: 15.17