HitPredict

Interactor 1: BMR1B (O00238)
Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
Gene: BMPR1B

Interactor 2: SMAD6 (O43541)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)
Gene: SMAD6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11483516, 9436979
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030509 - BMP signaling pathway GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Hs			1 496
+	Mm
		192363 BMR1B_MOUSE (1-502): 3.45e-156: 455: 98.21		SMAD6_MOUSE (1-496): 0: 694: 92.17
+	Mm
		192362 BMR1A_MOUSE (11-502): 6.49e-138: 410: 72.27		SMAD6_MOUSE (1-496): 0: 694: 92.17
+	Mm
		192364 ACVR1_MOUSE (19-499): 1.22e-137: 408: 49.49		SMAD6_MOUSE (1-496): 0: 694: 92.17
+	Hs
		206939 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		SMAD6_HUMAN (1-496): 0: 674: 100.00
+	Hs
		206941 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		SMAD6_HUMAN (1-496): 0: 674: 100.00
+	Hs
		206953 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		SMAD6_HUMAN (1-496): 0: 674: 100.00
+	Hs
		738353 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01
+	Hs
		738526 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		SMAD3_HUMAN (169-495): 2.34e-143: 419: 28.95
+	Hs
		981121 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		SMAD1_HUMAN (169-495): 9.29e-143: 419: 26.01
+	Hs
		981137 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		SMAD5_HUMAN (169-495): 1.6e-142: 419: 25.60
+	Hs
		738548 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		SMAD2_HUMAN (169-495): 3.35e-141: 415: 26.59
+	Hs
		167336 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		SMAD7_HUMAN (169-494): 7.2e-118: 354: 53.08
+	Hs
		167338 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		SMAD7_HUMAN (169-494): 7.2e-118: 354: 53.08
+	Hs
		167350 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		SMAD7_HUMAN (169-494): 7.2e-118: 354: 53.08
+	Mm
		192482 BMR1A_MOUSE (11-502): 6.49e-138: 410: 72.27		SMAD7_MOUSE (169-494): 2.48e-116: 350: 52.49
+	Mm
		192483 ACVR1_MOUSE (19-499): 1.22e-137: 408: 49.49		SMAD7_MOUSE (169-494): 2.48e-116: 350: 52.49
+	Dm
		1137192 Q95U21_DROME (1-499): 1.6e-138: 411: 41.60		Q5U110_DROME (177-496): 2.48e-102: 319: 34.45
+	Dm
		183440 Q7JQ39_DROME (1-499): 4.34e-137: 409: 41.60		O15968_DROME (177-496): 9.38e-102: 318: 34.45
+	Dm
		183441 Q95SI0_DROME (20-502): 1.01e-134: 401: 48.91		O15968_DROME (177-496): 9.38e-102: 318: 34.45
+	Hs
		738540 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		SMAD4_HUMAN (169-329): 1.68e-35: 140: 25.70