Protein: PICAL
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)

Gene: PICAL, PICALM
Organism: Homo sapiens
Interactions: 229
UniProt ID: Q13492

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001540 - amyloid-beta binding
GO:0005545 - 1-phosphatidylinositol binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036403

EPN4
Clathrin interactor 1

3

12

High-throughput

0.871

High

227372

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.754

High

237886

AP180
Clathrin coat assembly protein AP180

1

9

High-throughput

0.691

High

255318

HIP1R
Huntingtin-interacting protein 1-related protein

1

12

High-throughput

0.691

High

128849

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

3

1

High-throughput

0.675

High

863933

CLH2
Clathrin heavy chain 2

3

14

High-throughput

0.675

High

1036490

BMP2K
BMP-2-inducible protein kinase

3

19

High-throughput

0.675

High

1036494

GTSE1
G2 and S phase-expressed protein 1

3

6

High-throughput

0.675

High

787907

EPS15
Epidermal growth factor receptor substrate 15

3

12

High-throughput

0.670

High

451431

CLCA
Clathrin light chain A

3

11

High-throughput

0.667

High

451673

CLCB
Clathrin light chain B

3

11

High-throughput

0.667

High

1036503

MYO6
Unconventional myosin-VI

3

6

Small-scale

0.656

High

960778

CLH1
Clathrin heavy chain 1

2

14

Small-scale

0.639

High

321539

AP2A1
AP-2 complex subunit alpha-1

2

17

High-throughput

0.628

High

1036407

RBP1
RalA-binding protein 1

2

1

High-throughput

0.628

High

1036458

STALP
AMSH-like protease

2

3

High-throughput

0.628

High

397951

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.618

High

925862

AP2B1
AP-2 complex subunit beta

2

17

High-throughput

0.611

High

1036456

AP2M1
AP-2 complex subunit mu

2

3

Small-scale

0.611

High

473509

ATX1L
Ataxin-1-like

2

1

High-throughput

0.606

High

868474

ATX1
Ataxin-1

2

1

High-throughput

0.606

High

1036450

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

893978

CDC42
Cell division control protein 42 homolog

2

16

High-throughput

0.595

High

307529

EPN2
Epsin-2

1

14

High-throughput

0.590

High

1036509

EPN1
Epsin-1

1

11

High-throughput

0.590

High

1036402

FHL2
Four and a half LIM domains protein 2

1

3

Small-scale

0.586

High

384792

NTRK1
High affinity nerve growth factor receptor

2

11

High-throughput

0.584

High

915657

RHOB
Rho-related GTP-binding protein RhoB

2

18

High-throughput

0.584

High

1036461

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

581716

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

197706

CRX
Cone-rod homeobox protein

1

1

High-throughput

0.560

High

931139

YBOX1
Y-box-binding protein 1

2

0

Small-scale

0.559

High

529077

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.552

High

1036454

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

47772

RBM47
RNA-binding protein 47

1

1

High-throughput

0.536

High

161653

GAK
Cyclin-G-associated kinase

1

19

High-throughput

0.536

High

164876

SC16A
Protein transport protein Sec16A

1

4

High-throughput

0.536

High

181696

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

2

High-throughput

0.536

High

253740

AUXI
Auxilin

1

9

High-throughput

0.536

High

258011

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

323735

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

363129

FINC
Fibronectin

1

1

High-throughput

0.536

High

390867

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.536

High

455405

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.536

High

502066

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

609846

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.536

High

678871

HXA11
Homeobox protein Hox-A11

1

10

High-throughput

0.536

High

686652

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

724812

MYH9
Myosin-9

1

3

High-throughput

0.536

High

739103

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

762974

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

801123

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

813014

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

878178

SEC13
Protein SEC13 homolog

1

4

High-throughput

0.536

High

957175

DAB2
Disabled homolog 2

1

3

High-throughput

0.536

High

1001574

FCHO2
F-BAR domain only protein 2

1

4

High-throughput

0.536

High

1036398

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1036412

DREB
Drebrin

1

4

High-throughput

0.536

High

1036424

MTSS2
Protein MTSS 2

1

1

High-throughput

0.536

High

1036427

MICA3
[F-actin]-monooxygenase MICAL3

1

2

High-throughput

0.536

High

1036429

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.536

High

1036439

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1036440

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

High-throughput

0.536

High

1036443

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.536

High

1036445

DEN1A
DENN domain-containing protein 1A

1

4

High-throughput

0.536

High

1036452

STON2
Stonin-2

1

3

High-throughput

0.536

High

1036460

MYO19
Unconventional myosin-XIX

1

8

High-throughput

0.536

High

1036465

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1036468

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

1036471

RBM38
RNA-binding protein 38

1

5

High-throughput

0.536

High

1036487

ANLN
Anillin

1

3

High-throughput

0.536

High

1036488

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1036499

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.536

High

1036508

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.536

High

390215

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

518990

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

901920

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

1036400

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1036401

MLEC
Malectin

1

0

High-throughput

0.513

High

1036418

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

1036426

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1036433

ZN444
Zinc finger protein 444

1

0

High-throughput

0.513

High

1036441

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

1036447

DOK4
Docking protein 4

1

0

High-throughput

0.513

High

1036459

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

1036491

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1036504

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

1036506

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

147155

FCHO1
F-BAR domain only protein 1

1

4

Small-scale

0.501

High

174856

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

581002

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.501

High

1036486

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

Small-scale

0.501

High

473119

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

1

High-throughput

0.489

High

1036414

PRC2B
Protein PRRC2B

1

6

High-throughput

0.489

High

1036481

PAAT
ATPase PAAT

1

4

High-throughput

0.489

High

1036409

ITSN1
Intersectin-1

1

9

High-throughput

0.481

High

120422

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

134022

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

148771

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

162712

XPO1
Exportin-1

1

7

High-throughput

0.479

High

178521

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

205364

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

212825

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

272863

KS6A4
Ribosomal protein S6 kinase alpha-4

1

3

High-throughput

0.479

High

279544

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

308683

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

318128

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.479

High

338385

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

350145

RASK
GTPase KRas

1

5

High-throughput

0.479

High

453339

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

507984

FGFR1
Fibroblast growth factor receptor 1

1

8

High-throughput

0.479

High

525925

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

527442

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

530648

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

545359

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.479

High

552657

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

564516

RHOQ
Rho-related GTP-binding protein RhoQ

1

18

High-throughput

0.479

High

567047

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

610388

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

636918

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

651132

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

668654

PML
Protein PML

1

2

High-throughput

0.479

High

670015

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

684693

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

749463

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

781020

OPRD
Delta-type opioid receptor

1

4

Small-scale

0.479

High

813437

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

818020

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

835359

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.479

High

835731

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

841707

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

850650

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

High-throughput

0.479

High

872437

EPHA5
Ephrin type-A receptor 5

1

2

High-throughput

0.479

High

892355

RAC3
Ras-related C3 botulinum toxin substrate 3

1

14

High-throughput

0.479

High

901149

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

912889

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

914053

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

925257

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.479

High

950976

RHOG
Rho-related GTP-binding protein RhoG

1

12

High-throughput

0.479

High

965658

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

968301

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

12

High-throughput

0.479

High

968368

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

10

High-throughput

0.479

High

1036399

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.479

High

1036405

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1036406

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1036408

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.479

High

1036410

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.479

High

1036411

OCLN
Occludin

1

1

High-throughput

0.479

High

1036416

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1036417

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1036419

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1036421

STYK1
Tyrosine-protein kinase STYK1

1

3

High-throughput

0.479

High

1036422

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

1036423

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1036425

RHOU
Rho-related GTP-binding protein RhoU

1

18

High-throughput

0.479

High

1036428

ATG9A
Autophagy-related protein 9A

1

4

High-throughput

0.479

High

1036430

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1036432

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1036434

RHG18
Rho GTPase-activating protein 18

1

4

High-throughput

0.479

High

1036448

SMAP2
Stromal membrane-associated protein 2

1

3

High-throughput

0.479

High

1036453

MY18A
Unconventional myosin-XVIIIa

1

5

High-throughput

0.479

High

1036457

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.479

High

1036463

RHOV
Rho-related GTP-binding protein RhoV

1

16

High-throughput

0.479

High

1036464

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

1036466

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

2

High-throughput

0.479

High

1036474

DNJC5
DnaJ homolog subfamily C member 5

1

4

High-throughput

0.479

High

1036475

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

Small-scale

0.479

High

1036476

WNK1
Serine/threonine-protein kinase WNK1

1

8

High-throughput

0.479

High

1036477

RHOJ
Rho-related GTP-binding protein RhoJ

1

18

High-throughput

0.479

High

1036478

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1036482

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

1036483

WDR76
WD repeat-containing protein 76

1

4

High-throughput

0.479

High

1036485

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1036496

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1036498

HDAC6
Histone deacetylase 6

1

4

High-throughput

0.479

High

1036505

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

1036507

KLH20
Kelch-like protein 20

1

1

High-throughput

0.479

High

1036484

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

High-throughput

0.460

High

1036502

TEN1
Teneurin-1

1

0

Small-scale

0.460

High

305444

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

388881

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.458

High

521913

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

643746

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.458

High

793304

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.458

High

832434

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

961541

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

High-throughput

0.458

High

1036404

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1036413

FSCN1
Fascin

1

0

High-throughput

0.458

High

1036431

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1036446

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1036469

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1036473

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

1036493

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.458

High

1036495

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1036497

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.458

High

1036501

GGA2
ADP-ribosylation factor-binding protein GGA2

1

0

Small-scale

0.458

High

442131

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.457

High

965101

ANK2
Ankyrin-2

1

4

High-throughput

0.457

High

1021394

ANK3
Ankyrin-3

1

3

High-throughput

0.457

High

1036500

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

4

High-throughput

0.457

High

99458

F5GWT4
non-specific serine/threonine protein kinase

1

7

High-throughput

0.445

High

717789

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

968136

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.445

High

1036420

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.445

High

1036470

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

1036438

NECA1
N-terminal EF-hand calcium-binding protein 1

1

0

High-throughput

0.438

High

1036449

SNX33
Sorting nexin-33

1

0

High-throughput

0.438

High

1036462

ZN521
Zinc finger protein 521

1

0

High-throughput

0.438

High

100734

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

720393

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1036455

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1036472

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.437

High

1036492

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

371415

ANGI
Angiogenin

1

0

High-throughput

0.426

High

1036415

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.426

High

1036444

MIPT3
TRAF3-interacting protein 1

1

2

High-throughput

0.417

High

1036467

PIMRE
Protein PIMREG

2

0

High-throughput

0.318

High

1036436

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1036437

KTAP2
Keratinocyte-associated protein 2

1

0

High-throughput

0.279

Low

1036442

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

1036479

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.279

Low

1036480

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.279

Low

1036489

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.279

Low

279120

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

329702

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1036435

S2541
Mitochondrial carrier protein SCaMC-3L

1

0

High-throughput

0.249

Low

1036451

ITLN1
Intelectin-1

1

0

High-throughput

0.249

Low

393782

SCG1
Secretogranin-1

1

0

High-throughput

0.238

Low

484448

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024