HitPredict

Interactor 1: MEN1 (O00255)
Menin
Gene: MEN1

Interactor 2: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24981860, 14992727
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 610 Hs			1 5537
+	Hs
		123012 MEN1_HUMAN (1-610): 0: 1181: 100.00		EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17
+	Hs
		122944 MEN1_HUMAN (1-610): 0: 1181: 100.00		EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77
+	Hs
		122682 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24
+	Hs
		123091 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31
+	Hs
		122981 MEN1_HUMAN (1-610): 0: 1181: 100.00		NSD3_HUMAN (175-329): 6.17e-23: 111: 17.79
+	Hs
		122367 MEN1_HUMAN (1-610): 0: 1181: 100.00		SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15
+	Hs
		123099 MEN1_HUMAN (1-610): 0: 1181: 100.00		SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89
+	Hs
		122888 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2C_HUMAN (223-338): 3.09e-09: 66.3: 40.34