Protein: DISC
Protein disconnected

Gene: DISC, disco
Organism: Drosophila melanogaster
Interactions: 95
UniProt ID: P23792

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006355 - regulation of DNA-templated transcription
GO:0007420 - brain development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

84287

DIMM
Protein dimmed

3

0

High-throughput

0.633

High

593554

CF1A
POU domain protein CF1A

2

1

High-throughput

0.594

High

662819

OTP
Homeobox protein orthopedia

2

1

High-throughput

0.594

High

662820

DIF
Dorsal-related immunity factor Dif

2

1

High-throughput

0.594

High

662852

Q9V472
DLim1

2

1

High-throughput

0.594

High

662877

BFC
Transcriptional cofactor Bfc

2

1

High-throughput

0.594

High

197563

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.569

High

517332

HMH2
Homeobox protein H2.0

2

0

High-throughput

0.569

High

594734

7UP1
Steroid receptor seven-up, isoforms B/C

2

0

High-throughput

0.569

High

638282

SINA
E3 ubiquitin-protein ligase sina

2

0

High-throughput

0.569

High

662826

DICH
SOX domain-containing protein dichaete

2

0

High-throughput

0.569

High

662833

UNK
RING finger protein unkempt

2

0

High-throughput

0.569

High

662866

Q9VNS1
UT01871p

2

0

High-throughput

0.569

High

662867

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

0

High-throughput

0.569

High

662869

Q9VQ77
LD29420p

2

0

High-throughput

0.569

High

662870

ELBA2
Early boundary activity protein 2

2

0

High-throughput

0.569

High

662873

Q9VRY7
GH13213p

2

0

High-throughput

0.569

High

662876

Q9VZF2
LD05244p

2

0

High-throughput

0.569

High

662882

Q9W219
GEO12575p1

2

0

High-throughput

0.569

High

98462

F0JAK5
LD31195p

2

1

High-throughput

0.542

High

662830

Q7JR80
SD23764p

2

1

High-throughput

0.542

High

662843

Q8SZ28
RE21371p

2

1

High-throughput

0.542

High

662825

HR78
Nuclear hormone receptor HR78

1

1

High-throughput

0.541

High

662851

Q9TW27
DISCO interacting protein 1, isoform D

1

0

Small-scale

0.529

High

662858

Q9VHA4
LP19870p

1

0

High-throughput

0.518

High

662881

Q9W1H0
HL01030p

1

0

High-throughput

0.518

High

2289

A0A0B4KEQ7
Regulatory protein zeste

1

1

High-throughput

0.494

High

94814

E0R905
LP14345p

1

1

High-throughput

0.494

High

234453

CTBP
C-terminal-binding protein

1

0

High-throughput

0.486

High

662834

Q8INT9
Uncharacterized protein, isoform A

1

0

High-throughput

0.486

High

662862

PIRAG
Zinc finger protein piragua

1

0

High-throughput

0.486

High

662831

Q7K3Q3
Regulatory protein zeste

1

1

High-throughput

0.481

High

662832

Q7KSP5
Lethal

1

1

High-throughput

0.481

High

662839

Q8MLQ2
LIM zinc-binding domain-containing protein

1

1

High-throughput

0.481

High

662849

Q961B8
ADD domain-containing protein 1, isoform B

1

1

High-throughput

0.481

High

662889

X2JIB5
Uncharacterized protein, isoform D

1

1

High-throughput

0.481

High

662822

Q058W3
IP14616p

1

0

High-throughput

0.473

High

233510

SPY
Protein sprouty

1

1

High-throughput

0.464

High

118315

M9NDC4
Uncharacterized protein, isoform G

1

0

High-throughput

0.460

High

54567

A1Z8R2
ADD domain-containing protein 1, isoform A

1

1

High-throughput

0.457

High

662885

Q9W4F9
IP01388p

1

1

High-throughput

0.457

High

61211

A2VEE9
IP12305p

1

1

High-throughput

0.451

High

81847

B5X523
FI08059p

1

1

High-throughput

0.451

High

94174

D5SHL1
RT07968p

1

1

High-throughput

0.451

High

120186

M9PCK0
Decima, isoform D

1

1

High-throughput

0.451

High

662837

Q8IR14
RE66324p

1

1

High-throughput

0.451

High

662847

Q95T44
GH23604p

1

1

High-throughput

0.451

High

662865

Q9VM83
CG17376 protein

1

2

High-throughput

0.451

High

662868

Q9VQ16
LD20087p

1

1

High-throughput

0.451

High

96059

E8NH67
Asperous, isoform B

1

1

High-throughput

0.439

High

119648

M9PAZ8
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

120555

M9PDL4
Multiple wing hairs, isoform B

1

1

High-throughput

0.439

High

122360

M9PJA1
Uncharacterized protein, isoform F

1

1

High-throughput

0.439

High

662823

Q059C4
Decima, isoform C

1

1

High-throughput

0.439

High

662836

Q8IPI0
FI21287p1

1

1

High-throughput

0.439

High

662846

Q95SJ2
GEO04222p1

1

1

High-throughput

0.439

High

662872

Q9VR90
Syntaxin 16

1

3

High-throughput

0.439

High

662875

Q9VXG5
TNF-receptor-associated factor-like, isoform B

1

1

High-throughput

0.439

High

662887

R9PY70
Uncharacterized protein, isoform G

1

1

High-throughput

0.439

High

662888

X2JDF3
Uncharacterized protein, isoform C

1

2

High-throughput

0.439

High

662829

Q6NQZ3
LD16296p

1

0

High-throughput

0.438

High

662838

Q8IRH9
FI21268p1

1

1

High-throughput

0.417

High

662850

Q9GU66
Syntaxin

1

3

High-throughput

0.417

High

662863

Q9VM05
Uncharacterized protein, isoform A

1

1

High-throughput

0.417

High

662864

Q9VM81
Uncharacterized protein, isoform D

1

3

High-throughput

0.417

High

662886

Q9W5X1
Asperous, isoform A

1

1

High-throughput

0.417

High

98517

F0JAR8
MIP29201p

2

0

High-throughput

0.310

High

662827

Q4V3Z6
GEO02130p1

2

0

High-throughput

0.310

High

662828

Q4V473
GEO10190p1

2

0

High-throughput

0.310

High

662841

Q8SXN9
polynucleotide adenylyltransferase

2

0

High-throughput

0.310

High

662842

Q8SYC1
GEO08067p1

2

0

High-throughput

0.310

High

662845

Q8T3W6
AT27166p

2

0

High-throughput

0.310

High

662848

Q960F7
SD03629p

2

0

High-throughput

0.310

High

662855

Q9VAY6
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.310

High

662856

Q9VCX6
AT09144p

2

0

High-throughput

0.310

High

662857

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

0

High-throughput

0.310

High

662860

Q9VJM5
GH06096p

2

0

High-throughput

0.310

High

662861

Q9VLC8
AT19071p

2

0

High-throughput

0.310

High

662871

Q9VQK1
Ccdc85

2

0

High-throughput

0.310

High

662880

Q9W1B2
MICOS complex subunit MIC10

2

0

High-throughput

0.310

High

662884

Q9W483
GH18971p

2

0

High-throughput

0.310

High

467051

MS87F
Male-specific sperm protein Mst87F

1

0

High-throughput

0.265

Low

662821

MS84C
Male-specific sperm protein Mst84Dc

1

0

High-throughput

0.265

Low

662824

ROP
Protein ROP

1

0

High-throughput

0.265

Low

662835

Q8IP27
AT25112p

1

0

High-throughput

0.265

Low

662844

HIPPO
Serine/threonine-protein kinase hippo

1

0

High-throughput

0.265

Low

662853

Q9VAA1
RH14395p

1

0

High-throughput

0.265

Low

662854

Q9VAU6
LD27564p

1

0

High-throughput

0.265

Low

662859

Q9VJM1
GEO13348p1

1

0

High-throughput

0.265

Low

662874

BI1
Bax inhibitor 1

1

0

High-throughput

0.265

Low

662883

Q9W3H4
LD36273p

1

0

High-throughput

0.265

Low

662840

Q8MYU0
Fledgling of Klp38B, isoform A

1

0

High-throughput

0.257

Low

662878

WAGC
Augmin complex subunit wac

1

0

High-throughput

0.257

Low

118004

M9MRX2
Fledgling of Klp38B, isoform E

1

0

High-throughput

0.251

Low

662879

DIP2
Disco-interacting protein 2

1

0

High-throughput

0.198

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025