HitPredict

Interactor 1: RCOR2 (Q8IZ40)
REST corepressor 2
Gene: RCOR2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	35271311, 21258344, 23752268
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 523 Hs			1 488
+	Mm
		936416 RCOR2_MOUSE (1-523): 2.53e-143: 424: 97.51		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1270488 RCOR3_HUMAN (46-520): 8.7e-129: 386: 57.20		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038521 RCOR2_HUMAN (1-523): 2.13e-143: 424: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		296092 MTA2_HUMAN (12-512): 1.27e-102: 324: 17.50		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936428 MTA2_MOUSE (12-512): 8.67e-104: 327: 17.14		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1038768 RCOR3_HUMAN (46-520): 8.7e-129: 386: 57.20		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270515 RCOR1_HUMAN (16-425): 1.79e-102: 318: 51.44		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936418 RCOR1_MOUSE (16-425): 1.84e-103: 320: 51.43		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1031919 MTA1_HUMAN (26-474): 1.9e-97: 311: 17.00		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936419 MTA1_MOUSE (26-474): 3.01e-98: 314: 16.80		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Mm
		140317 MTA2_MOUSE (12-512): 8.67e-104: 327: 17.14		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		296017 MTA2_HUMAN (12-512): 1.27e-102: 324: 17.50		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140301 RCOR1_MOUSE (16-425): 1.84e-103: 320: 51.43		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038801 RCOR1_HUMAN (16-425): 1.79e-102: 318: 51.44		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177395 RCOR3_HUMAN (46-520): 8.7e-129: 386: 57.20		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		140302 MTA1_MOUSE (26-474): 3.01e-98: 314: 16.80		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Dm
		1276548 Q9VNF6_DROME (23-507): 1.38e-93: 305: 13.81		HDAC1_DROME (5-472): 0: 653: 77.92
+	Dm
		81423 B7Z0T5_DROME (23-507): 1.05e-93: 305: 13.81		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1031849 MTA1_HUMAN (26-474): 1.9e-97: 311: 17.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177402 RCOR1_HUMAN (16-425): 1.79e-102: 318: 51.44		HDAC3_HUMAN (10-431): 0: 574: 58.26