HitPredict

Interactor 1: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	23414517
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008092 - cytoskeletal protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 1292
+	Hs
		203250 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		SRBS1_HUMAN (1-1292): 5.5e-176: 558: 100.00
+	Hs
		537660 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCF1_HUMAN (701-1015): 3.76e-50: 185: 17.18
+	Hs
		557737 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		360650 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		SPTA1_HUMAN (303-1028): 9.45e-45: 180: 9.89
+	Mm
		997647 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		NCF1_MOUSE (674-1015): 2.6e-48: 179: 15.91
+	Hs
		209108 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Mm
		223016 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		NCK2_MOUSE (761-1019): 5.71e-43: 163: 16.61
+	Hs
		1052249 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Mm
		1208107 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		PACN2_MOUSE (1024-1290): 7.78e-24: 109: 16.12
+	Hs
		298987 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		557806 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		209180 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Hs
		203208 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		235603 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59
+	Ce
		711201 Q10929_CAEEL (3-503): 2.93e-67: 225: 28.94		YKA7_CAEEL (786-925): 3.58e-13: 75.7: 20.95
+	Hs
		203224 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		203228 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		203192 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		203230 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		203191 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59