HitPredict

Interactor 1: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Interactor 2: ES8L2 (Q9H6S3)
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene: EPS8L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14565974
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 715
+	Hs
		1020381 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		EPS8_HUMAN (2-715): 0: 745: 39.73
+	Mm
		995948 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		EPS8_MOUSE (2-715): 0: 743: 38.42
+	Hs
		1224620 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ES8L1_HUMAN (19-713): 0: 653: 38.16
+	Mm
		913884 ABI2_MOUSE (1-508): 4.85e-88: 279: 61.18		EPS8_MOUSE (2-715): 0: 743: 38.42
+	Hs
		1224619 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ES8L3_HUMAN (24-688): 4e-165: 489: 28.11
+	Hs
		433413 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		YES_HUMAN (381-709): 1.86e-76: 257: 15.22
+	Hs
		454841 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		FGR_HUMAN (418-709): 4.52e-76: 256: 15.72
+	Hs
		412258 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		FYN_HUMAN (431-709): 8.42e-70: 239: 14.94
+	Hs
		523060 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		442853 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		HCK_HUMAN (430-715): 6.22e-66: 228: 13.09
+	Hs
		433885 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		LYN_HUMAN (431-709): 1.93e-62: 218: 13.64
+	Hs
		411788 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		LCK_HUMAN (416-715): 1.35e-60: 213: 12.79
+	Hs
		996567 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ITK_HUMAN (398-715): 6.86e-56: 203: 16.22
+	Hs
		789126 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		FRK_HUMAN (459-651): 7.21e-42: 161: 17.96
+	Hs
		209108 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77
+	Mm
		223016 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		NCK2_MOUSE (492-556): 1.12e-19: 93.8: 30.77
+	Hs
		557737 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69
+	Hs
		209180 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77
+	Hs
		3136 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		A0A0S2Z4D7_HUMAN (492-556): 6.64e-18: 83.8: 27.69
+	Hs
		3146 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		A0A0S2Z4E4_HUMAN (492-556): 6.05e-17: 83: 27.69