HitPredict

Interactor 1: SPART (Q8N0X7)
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)
Gene: SPART

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 666 Hs			1 1572
+	Hs
		1350491 SPAST_HUMAN (9-458): 7.59e-112: 351: 16.94		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		875071 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Sc
		636723 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		TOM1_YEAST (1159-1571): 1.28e-153: 523: 35.73
+	Hs
		1229727 SPART_HUMAN (1-666): 0: 631: 100.00		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		125574 SPART_HUMAN (1-666): 0: 631: 100.00		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1229721 SPART_HUMAN (1-666): 0: 631: 100.00		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		1229725 SPART_HUMAN (1-666): 0: 631: 100.00		SMUF2_HUMAN (653-842): 7.63e-13: 75.6: 18.85
+	Hs
		1229716 SPART_HUMAN (1-666): 0: 631: 100.00		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		875337 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Sc
		636637 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		RSP5_YEAST (572-850): 1.92e-11: 71: 16.10