Protein: SYVC
Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)

Gene: SYVC, VARS1
Organism: Homo sapiens
Interactions: 192
UniProt ID: P26640

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004832 - valine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687748

EF1G
Elongation factor 1-gamma

6

4

Small-scale

0.945

High

687752

EF1D
Elongation factor 1-delta

5

5

Small-scale

0.712

High

370569

FOS
Protein c-Fos

4

11

High-throughput

0.699

High

687754

COR1A
Coronin-1A

3

9

High-throughput

0.667

High

687782

EF1A1
Elongation factor 1-alpha 1

3

7

Small-scale

0.662

High

345396

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

5

High-throughput

0.640

High

687789

EF1A2
Elongation factor 1-alpha 2

4

7

High-throughput

0.633

High

687847

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

2

4

High-throughput

0.628

High

687882

SYLC
Leucine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.618

High

461170

HS90A
Heat shock protein HSP 90-alpha

2

10

High-throughput

0.611

High

687800

CUL3
Cullin-3

2

7

High-throughput

0.611

High

584066

FOSL2
Fos-related antigen 2

3

5

High-throughput

0.609

High

687885

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.606

High

240806

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

687825

RICTR
Rapamycin-insensitive companion of mTOR

2

3

High-throughput

0.584

High

687840

SERB1
SERPINE1 mRNA-binding protein 1

2

4

High-throughput

0.584

High

687884

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

687769

AF17
Protein AF-17

2

1

High-throughput

0.574

High

687796

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.573

High

249721

DOK2
Docking protein 2

2

1

High-throughput

0.571

High

395526

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

439957

LCK
Tyrosine-protein kinase Lck

2

4

High-throughput

0.571

High

440382

FYN
Tyrosine-protein kinase Fyn

2

4

High-throughput

0.571

High

584706

NDKA
Nucleoside diphosphate kinase A

2

3

High-throughput

0.571

High

603170

KPCA
Protein kinase C alpha type

2

5

High-throughput

0.571

High

619515

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.571

High

631068

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

687786

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

9

High-throughput

0.571

High

687788

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

2

High-throughput

0.571

High

687807

KPCD1
Serine/threonine-protein kinase D1

2

6

High-throughput

0.571

High

687814

DUS6
Dual specificity protein phosphatase 6

2

3

High-throughput

0.571

High

583997

FOSL1
Fos-related antigen 1

2

7

High-throughput

0.549

High

687792

FOXC1
Forkhead box protein C1

1

18

High-throughput

0.536

High

687809

MK11
Mitogen-activated protein kinase 11

1

8

High-throughput

0.536

High

687812

PKN2
Serine/threonine-protein kinase N2

1

9

High-throughput

0.536

High

687819

BOREA
Borealin

1

1

High-throughput

0.536

High

687830

HAKAI
E3 ubiquitin-protein ligase Hakai

1

2

Small-scale

0.536

High

687849

ERP27
Endoplasmic reticulum resident protein 27

1

1

High-throughput

0.536

High

687850

OTUD5
OTU domain-containing protein 5

1

5

High-throughput

0.536

High

687857

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.536

High

687874

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

9

High-throughput

0.536

High

687878

BET1L
BET1-like protein

1

2

High-throughput

0.536

High

371215

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.533

High

687804

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

3

Small-scale

0.533

High

687766

CAV2
Caveolin-2

2

2

High-throughput

0.521

High

687795

DUS4
Dual specificity protein phosphatase 4

2

3

High-throughput

0.521

High

687836

SLX4
Structure-specific endonuclease subunit SLX4

2

4

High-throughput

0.521

High

687856

SH3G3
Endophilin-A3

2

1

High-throughput

0.521

High

538879

EPB41
Protein 4.1

1

2

High-throughput

0.515

High

624220

TFE3
Transcription factor E3

1

2

High-throughput

0.515

High

687759

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

687888

TRAF6
TNF receptor-associated factor 6

1

10

High-throughput

0.515

High

687798

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.515

High

687772

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

687813

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

687844

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.513

High

687873

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

429338

JUN
Transcription factor Jun

1

12

High-throughput

0.506

High

687749

1433T
14-3-3 protein theta

1

11

High-throughput

0.501

High

687775

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.501

High

687845

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.501

High

687846

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.493

High

133084

FOXE1
Forkhead box protein E1

1

14

High-throughput

0.489

High

186835

FOXN1
Forkhead box protein N1

1

15

High-throughput

0.489

High

288067

FOXH1
Forkhead box protein H1

1

19

High-throughput

0.489

High

687760

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.489

High

687767

CEBPG
CCAAT/enhancer-binding protein gamma

1

13

High-throughput

0.489

High

687770

FOXG1
Forkhead box protein G1

1

15

High-throughput

0.489

High

687771

FOXA1
Hepatocyte nuclear factor 3-alpha

1

17

High-throughput

0.489

High

687773

FOXL2
Forkhead box protein L2

1

14

High-throughput

0.489

High

687790

DMWD
Dystrophia myotonica WD repeat-containing protein

1

9

High-throughput

0.489

High

687793

FOXI1
Forkhead box protein I1

1

15

High-throughput

0.489

High

687794

FOXL1
Forkhead box protein L1

1

15

High-throughput

0.489

High

687827

FOXI2
Forkhead box protein I2

1

14

High-throughput

0.489

High

687855

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.489

High

687863

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.489

High

122917

SGK1
Serine/threonine-protein kinase Sgk1

1

6

High-throughput

0.479

High

143560

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.479

High

285092

EED
Polycomb protein EED

1

13

High-throughput

0.479

High

362803

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.479

High

379883

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

400308

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

411394

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

536542

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

618434

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

2

High-throughput

0.479

High

659361

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

667541

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

687751

SHC1
SHC-transforming protein 1

1

7

High-throughput

0.479

High

687755

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

687758

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

687764

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

687765

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

687768

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

687776

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

687779

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

687781

1433Z
14-3-3 protein zeta/delta

1

11

High-throughput

0.479

High

687783

RED1
Double-stranded RNA-specific editase 1

1

6

High-throughput

0.479

High

687785

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.479

High

687791

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

687797

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

687802

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.479

High

687805

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

687806

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

687818

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

687823

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

687833

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

687843

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

687848

ARMC5
Armadillo repeat-containing protein 5

1

3

High-throughput

0.479

High

687852

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

687853

KI20B
Kinesin-like protein KIF20B

1

7

High-throughput

0.479

High

687858

DERL1
Derlin-1

1

1

Small-scale

0.479

High

687859

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.479

High

687862

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

High-throughput

0.479

High

687866

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

687867

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

687872

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

687875

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

687877

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

4

High-throughput

0.479

High

687881

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

5

High-throughput

0.479

High

687889

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

687890

NEMO
NF-kappa-B essential modulator

1

8

High-throughput

0.479

High

139685

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

2

High-throughput

0.464

High

687761

MTR1A
Melatonin receptor type 1A

1

2

High-throughput

0.464

High

687753

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

687879

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

687777

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.457

High

687841

JDP2
Jun dimerization protein 2

1

5

Small-scale

0.457

High

529128

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

626081

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

High-throughput

0.445

High

665379

EF1B
Elongation factor 1-beta

1

4

Small-scale

0.445

High

687799

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.445

High

687865

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.445

High

687886

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.445

High

533594

CLUS
Clusterin

1

0

High-throughput

0.438

High

105379

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

324558

HEXI1
Protein HEXIM1

1

2

High-throughput

0.437

High

389054

FINC
Fibronectin

1

6

High-throughput

0.437

High

418842

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

565164

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

587964

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

590808

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

606260

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.437

High

687750

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

687756

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

687757

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.437

High

687762

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

687778

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

687780

H4
Histone H4

1

2

High-throughput

0.437

High

687787

CREM
cAMP-responsive element modulator

1

2

Small-scale

0.437

High

687801

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

687803

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.437

High

687808

SF01
Splicing factor 1

1

2

High-throughput

0.437

High

687811

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

687817

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

687821

OTUD1
OTU domain-containing protein 1

1

2

High-throughput

0.437

High

687822

TENS2
Tensin-2

1

3

High-throughput

0.437

High

687824

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.437

High

687826

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

687828

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

687829

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.437

High

687831

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

687835

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

687839

POC5
Centrosomal protein POC5

1

1

High-throughput

0.437

High

687842

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

High-throughput

0.437

High

687860

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

687861

YTHD1
YTH domain-containing family protein 1

1

6

High-throughput

0.437

High

687868

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

687870

WDR76
WD repeat-containing protein 76

1

14

High-throughput

0.437

High

687871

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.437

High

687876

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

687880

DAPLE
Protein Daple

1

5

High-throughput

0.437

High

687883

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

687887

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

687834

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

133440

ACATN
Acetyl-coenzyme A transporter 1

1

1

High-throughput

0.407

High

687838

SVOPL
Putative transporter SVOPL

1

5

High-throughput

0.407

High

687869

VIAAT
Vesicular inhibitory amino acid transporter

1

2

High-throughput

0.407

High

687763

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.373

High

587009

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

687815

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

176028

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

687784

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

687820

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

687832

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.249

Low

687837

NXPE1
NXPE family member 1

1

0

High-throughput

0.249

Low

687774

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

62452

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

687810

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

687816

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

0

High-throughput

0.232

Low

687851

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

687854

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low

687864

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025