HitPredict

Interactor 1: SIX5 (Q8N196)
Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)
Gene: SIX5

Interactor 2: EYA3 (Q99504)
Eyes absent homolog 3 (EC 3.1.3.48)
Gene: EYA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	10490620, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 739 Hs			1 573
+	Hs
		1230644 SIX5_HUMAN (1-739): 1.42e-101: 330: 100.00		EYA1_HUMAN (27-573): 0: 791: 52.24
+	Hs
		1304309 SIX2_HUMAN (82-358): 3.46e-94: 296: 43.68		EYA3_HUMAN (1-573): 0: 822: 100.00
+	Hs
		318670 SIX5_HUMAN (1-739): 1.42e-101: 330: 100.00		EYA4_HUMAN (23-573): 0: 787: 53.32
+	Mm
		956884 SIX4_MOUSE (13-710): 1.32e-95: 315: 28.73		EYA1_MOUSE (27-573): 0: 795: 52.70
+	Hs
		1304297 SIX4_HUMAN (13-716): 7.23e-95: 313: 28.76		EYA1_HUMAN (27-573): 0: 791: 52.24
+	Hs
		318748 SIX4_HUMAN (13-716): 7.23e-95: 313: 28.76		EYA4_HUMAN (23-573): 0: 787: 53.32
+	Mm
		936193 SIX5_MOUSE (1-739): 6.98e-90: 299: 82.00		EYA1_MOUSE (27-573): 0: 795: 52.70
+	Hs
		1304296 SIX2_HUMAN (82-358): 3.46e-94: 296: 43.68		EYA1_HUMAN (27-573): 0: 791: 52.24
+	Hs
		318733 SIX2_HUMAN (82-358): 3.46e-94: 296: 43.68		EYA4_HUMAN (23-573): 0: 787: 53.32
+	Mm
		956886 SIX2_MOUSE (82-358): 1.02e-90: 287: 43.62		EYA1_MOUSE (27-573): 0: 795: 52.70
+	Hs
		92588 SIX2_HUMAN (82-358): 3.46e-94: 296: 43.68		E9PLN6_HUMAN (20-573): 0: 782: 53.75
+	Hs
		318622 SIX1_HUMAN (82-355): 2.62e-89: 283: 42.34		EYA4_HUMAN (23-573): 0: 787: 53.32
+	Hs
		92587 SIX1_HUMAN (82-355): 2.62e-89: 283: 42.34		E9PLN6_HUMAN (20-573): 0: 782: 53.75
+	Hs
		118619 SIX4_HUMAN (13-716): 7.23e-95: 313: 28.76		EYA2_HUMAN (60-573): 0: 728: 48.84
+	Mm
		139225 SIX4_MOUSE (13-710): 1.32e-95: 315: 28.73		EYA2_MOUSE (24-573): 0: 711: 46.92
+	Hs
		118611 SIX2_HUMAN (82-358): 3.46e-94: 296: 43.68		EYA2_HUMAN (60-573): 0: 728: 48.84
+	Hs
		118562 SIX1_HUMAN (82-355): 2.62e-89: 283: 42.34		EYA2_HUMAN (60-573): 0: 728: 48.84
+	Mm
		936192 SIX5_MOUSE (1-739): 6.98e-90: 299: 82.00		EYA3_MOUSE (17-573): 0: 693: 84.38
+	Dm
		983459 SO_DROME (82-344): 2.89e-97: 309: 46.21		EYA_DROME (96-573): 2.53e-156: 467: 40.85
+	Ce
		184785 HM33_CAEEL (74-309): 1.61e-93: 293: 43.04		EYA1_CAEEL (97-569): 7.72e-84: 272: 23.26