HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 560 Hs			1 441
+	Mm
		1265551 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268064 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Hs
		267830 CBX7_HUMAN (1-250): 1.04e-38: 144: 30.71		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1265610 CBX8_MOUSE (1-335): 1.59e-33: 133: 23.67		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268291 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Hs
		1059181 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29
+	Hs
		1288395 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29
+	Hs
		1281401 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32
+	Hs
		800458 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		DAW1_HUMAN (292-439): 3.56e-20: 93.8: 13.91
+	Hs
		903191 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		1288317 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29
+	Hs
		203735 SUV91_HUMAN (4-154): 1.01e-32: 131: 21.15		DAW1_HUMAN (292-439): 3.56e-20: 93.8: 13.91
+	Hs
		1335779 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09
+	Hs
		903125 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		903532 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Dm
		639957 PC_DROME (10-237): 5.16e-28: 117: 21.49		TAF5_DROME (85-367): 9.54e-17: 84.8: 17.48
+	Dm
		639962 PC_DROME (10-237): 5.16e-28: 117: 21.49		ESC_DROME (23-226): 5.01e-10: 63: 8.10