Protein: RPGF3
Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)

Gene: RPGF3, RAPGEF3
Organism: Homo sapiens
Interactions: 22
UniProt ID: O95398

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002250 - adaptive immune response
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005886 - plasma membrane
GO:0005902 - microvillus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335725

DAPK1
Death-associated protein kinase 1

1

8

High-throughput

0.692

High

335721

RAP2A
Ras-related protein Rap-2a

1

20

Small-scale

0.647

High

335728

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

335726

RAP1B
Ras-related protein Rap-1b

1

20

Small-scale

0.618

High

335731

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

2

Small-scale

0.597

High

335739

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.589

High

335727

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.586

High

335723

RBP2
E3 SUMO-protein ligase RanBP2

2

4

Small-scale

0.584

High

335730

MAP1A
Microtubule-associated protein 1A

1

7

Small-scale

0.479

High

335732

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

335720

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.460

High

335722

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

High-throughput

0.460

High

335729

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.460

High

335736

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.460

High

335733

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

0

Small-scale

0.458

High

335738

NU205
Nuclear pore complex protein Nup205

1

0

Small-scale

0.458

High

335740

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.439

High

335724

NUP98
Nuclear pore complex protein Nup98-Nup96

1

1

Small-scale

0.437

High

335735

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

335734

UFSP1
Ufm1-specific protease 1

1

0

High-throughput

0.251

Low

335737

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.251

Low

335741

OARD1
ADP-ribose glycohydrolase OARD1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025