HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30317550, 11583618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0051219 - phosphoprotein binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 560 Hs			1 928
+	Hs
		414266 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		RB_HUMAN (1-928): 0: 1323: 100.00
+	Hs
		414208 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		RB_HUMAN (1-928): 0: 1323: 100.00
+	Hs
		414241 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		RB_HUMAN (1-928): 0: 1323: 100.00
+	Hs
		203615 SUV91_HUMAN (4-154): 1.01e-32: 131: 21.15		RB_HUMAN (1-928): 0: 1323: 100.00
+	Hs
		203630 SUV91_HUMAN (4-154): 1.01e-32: 131: 21.15		RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92
+	Mm
		613029 CBX3_MOUSE (9-163): 1.02e-43: 155: 21.29		RBL2_MOUSE (627-875): 1.04e-57: 217: 24.92
+	Mm
		1143023 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		RBL2_MOUSE (627-875): 1.04e-57: 217: 24.92
+	Mm
		949939 CBX1_MOUSE (17-163): 1.89e-39: 144: 21.05		RBL2_MOUSE (627-875): 1.04e-57: 217: 24.92
+	Rn
		69935 B1H256_RAT (4-154): 3.05e-34: 136: 22.44		RBL2_RAT (558-875): 3.72e-57: 216: 21.39
+	Hs
		203671 SUV91_HUMAN (4-154): 1.01e-32: 131: 21.15		RBL2_HUMAN (638-875): 1.32e-58: 220: 26.87