Protein: CO1A1
Collagen alpha-1(I) chain (Alpha-1 type I collagen)

Gene: CO1A1, COL1A1
Organism: Homo sapiens
Interactions: 159
UniProt ID: P02452

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001503 - ossification
GO:0001568 - blood vessel development
GO:0001649 - osteoblast differentiation
GO:0001957 - intramembranous ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

358452

CO1A2
Collagen alpha-2(I) chain

3

17

Small-scale

0.839

High

358450

TSP1
Thrombospondin-1

2

9

Small-scale

0.778

High

179997

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

3

5

Small-scale

0.675

High

358528

CMKMT
Calmodulin-lysine N-methyltransferase

3

1

High-throughput

0.667

High

358444

VWF
von Willebrand factor

1

15

Small-scale

0.647

High

358487

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

19

Small-scale

0.647

High

358498

CO7A1
Collagen alpha-1(VII) chain

1

19

Small-scale

0.647

High

358441

FINC
Fibronectin

3

18

Small-scale

0.646

High

358456

SPRC
SPARC

3

5

Small-scale

0.646

High

358532

YAF2
YY1-associated factor 2

2

1

High-throughput

0.628

High

358533

GT252
Procollagen galactosyltransferase 2

2

20

High-throughput

0.628

High

358479

CO8A2
Collagen alpha-2(VIII) chain

1

20

Small-scale

0.618

High

271508

ERAL1
GTPase Era, mitochondrial

3

2

High-throughput

0.609

High

358512

KEAP1
Kelch-like ECH-associated protein 1

2

4

High-throughput

0.606

High

358499

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

3

20

Small-scale

0.604

High

358470

CO5A1

1

17

Small-scale

0.590

High

358524

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.585

High

358541

GIPC2
PDZ domain-containing protein GIPC2

2

0

High-throughput

0.585

High

358570

DYN3
Dynamin-3

2

0

High-throughput

0.585

High

358475

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

4

Small-scale

0.585

High

358469

IBP3
Insulin-like growth factor-binding protein 3

1

5

Small-scale

0.581

High

358439

CO1A1
Collagen alpha-1(I) chain

1

18

Small-scale

0.575

High

358440

CO2A1
Collagen alpha-1(II) chain

1

18

Small-scale

0.575

High

208498

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

2

High-throughput

0.574

High

350940

PDGFB
Platelet-derived growth factor subunit B

1

11

Small-scale

0.536

High

236394

RNBP6
Ran-binding protein 6

1

1

High-throughput

0.536

High

274398

CRTAP
Cartilage-associated protein

1

2

Small-scale

0.536

High

358447

PDIA1
Protein disulfide-isomerase

1

8

Small-scale

0.536

High

358462

PDIA4
Protein disulfide-isomerase A4

1

8

Small-scale

0.536

High

358463

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

5

Small-scale

0.536

High

358478

PAX3
Paired box protein Pax-3

1

3

High-throughput

0.536

High

358483

ERP29
Endoplasmic reticulum resident protein 29

1

9

Small-scale

0.536

High

358484

PDIA3
Protein disulfide-isomerase A3

1

8

Small-scale

0.536

High

358489

R144A
E3 ubiquitin-protein ligase RNF144A

1

1

High-throughput

0.536

High

358491

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

358493

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

358496

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.536

High

358502

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.536

High

358518

RCN1
Reticulocalbin-1

1

1

Small-scale

0.536

High

358527

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

12

High-throughput

0.536

High

358535

CBLL2
E3 ubiquitin-protein ligase CBLL2

1

2

High-throughput

0.536

High

358536

GT251
Procollagen galactosyltransferase 1

1

20

Small-scale

0.536

High

358553

ERP44
Endoplasmic reticulum resident protein 44

1

9

Small-scale

0.536

High

358566

DJB11
DnaJ homolog subfamily B member 11

1

1

Small-scale

0.536

High

358567

KLF15
Krueppel-like factor 15

1

2

High-throughput

0.536

High

358571

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

High-throughput

0.536

High

358573

CHMP3
Charged multivesicular body protein 3

1

4

High-throughput

0.536

High

358574

HYOU1
Hypoxia up-regulated protein 1

1

3

Small-scale

0.536

High

358451

SP1
Transcription factor Sp1

1

4

Small-scale

0.534

High

358510

SMAD4
Mothers against decapentaplegic homolog 4

1

16

Small-scale

0.534

High

358459

THIO
Thioredoxin

1

5

Small-scale

0.527

High

169695

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

4

Small-scale

0.515

High

58339

TESP1
Protein TESPA1

1

0

High-throughput

0.513

High

239019

CTND1
Catenin delta-1

1

0

High-throughput

0.513

High

358472

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.513

High

358506

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

358529

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.513

High

358531

BRSK2
Serine/threonine-protein kinase BRSK2

1

0

High-throughput

0.513

High

358542

TRI41
E3 ubiquitin-protein ligase TRIM41

1

0

High-throughput

0.513

High

358544

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.513

High

358547

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.513

High

358549

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

358551

ERO1A
ERO1-like protein alpha

1

0

Small-scale

0.513

High

358555

ABHEA
Protein ABHD14A

1

0

High-throughput

0.513

High

126331

MATN2
Matrilin-2

1

6

Small-scale

0.501

High

203012

COCH
Cochlin

1

13

Small-scale

0.501

High

358443

PDGFA
Platelet-derived growth factor subunit A

1

11

Small-scale

0.501

High

358454

MMP2
72 kDa type IV collagenase

1

20

Small-scale

0.501

High

358465

NID1
Nidogen-1

1

4

Small-scale

0.501

High

358471

MAG
Myelin-associated glycoprotein

1

5

Small-scale

0.501

High

358474

PGS1
Biglycan

1

3

Small-scale

0.501

High

358490

PRELP
Prolargin

1

3

Small-scale

0.501

High

358495

PKD1
Polycystin-1

1

1

Small-scale

0.501

High

358504

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.501

High

358511

NID2
Nidogen-2

1

4

Small-scale

0.501

High

358520

DDR2
Discoidin domain-containing receptor 2

1

7

Small-scale

0.501

High

358460

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.500

High

358466

ENPL
Endoplasmin

1

2

Small-scale

0.500

High

358476

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

Small-scale

0.500

High

358488

SERPH
Serpin H1

1

2

Small-scale

0.500

High

358548

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

4

Small-scale

0.500

High

358521

TMM44
Transmembrane protein 44

1

1

High-throughput

0.489

High

358486

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.481

High

358538

MCPH1
Microcephalin

1

1

Small-scale

0.481

High

358552

BARD1
BRCA1-associated RING domain protein 1

1

1

High-throughput

0.481

High

358458

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

358492

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

204901

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

337729

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

358461

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

358485

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

358494

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.479

High

358507

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

358519

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

358534

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

358556

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

358557

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

358515

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

1

12

High-throughput

0.470

High

358449

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.460

High

358473

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.460

High

302760

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

358540

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.458

High

358543

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

358526

LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

1

12

Small-scale

0.457

High

358445

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.457

High

358467

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.457

High

358482

LYOX
Protein-lysine 6-oxidase

1

2

Small-scale

0.457

High

358545

HTRA1
Serine protease HTRA1

1

1

Small-scale

0.457

High

216133

CALU
Calumenin

1

1

Small-scale

0.445

High

237005

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

20

Small-scale

0.445

High

358442

ANXA1
Annexin A1

1

4

Small-scale

0.445

High

358446

ITB1
Integrin beta-1

1

4

Small-scale

0.445

High

358448

ANXA2
Annexin A2

1

4

Small-scale

0.445

High

358453

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.445

High

358468

ITA2
Integrin alpha-2

1

8

Small-scale

0.445

High

358480

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.445

High

358501

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.445

High

358509

PRDX4
Peroxiredoxin-4

1

1

Small-scale

0.445

High

358517

PDIA6
Protein disulfide-isomerase A6

1

8

Small-scale

0.445

High

358522

P3H1
Prolyl 3-hydroxylase 1

1

2

Small-scale

0.445

High

358530

P3H3
Prolyl 3-hydroxylase 3

1

2

Small-scale

0.445

High

358537

TXND5
Thioredoxin domain-containing protein 5

1

8

Small-scale

0.445

High

358554

NTPCR
Cancer-related nucleoside-triphosphatase

1

1

High-throughput

0.437

High

358561

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

358562

ANLN
Anillin

1

2

High-throughput

0.437

High

358455

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.426

High

358464

GLU2B
Glucosidase 2 subunit beta

1

0

Small-scale

0.426

High

358477

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.426

High

358481

CALR
Calreticulin

1

0

Small-scale

0.426

High

358497

ANK2
Ankyrin-2

1

0

High-throughput

0.426

High

358503

CKAP4
Cytoskeleton-associated protein 4

1

0

Small-scale

0.426

High

358508

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

Small-scale

0.426

High

358513

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.426

High

358514

MVP
Major vault protein

1

0

Small-scale

0.426

High

358564

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.426

High

358569

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

Small-scale

0.426

High

358457

ARMS2
Age-related maculopathy susceptibility protein 2

1

1

Small-scale

0.417

High

358546

AP2C
Transcription factor AP-2 gamma

1

4

High-throughput

0.417

High

358563

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

129876

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

20

Small-scale

0.407

High

311307

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

1

4

Small-scale

0.407

High

358572

CNPY2
Protein canopy homolog 2

1

1

Small-scale

0.407

High

358523

UBX11
UBX domain-containing protein 11

3

0

High-throughput

0.347

High

358500

TLE3
Transducin-like enhancer protein 3

2

0

High-throughput

0.328

High

358505

RGF1B
Ras-GEF domain-containing family member 1B

2

0

High-throughput

0.328

High

358525

LIN9
Protein lin-9 homolog

2

0

High-throughput

0.328

High

358550

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.298

High

358560

AT132
Polyamine-transporting ATPase 13A2

1

0

Small-scale

0.282

High

129364

GOLI4
Golgi integral membrane protein 4

1

0

Small-scale

0.279

Low

358539

S2540
Mitochondrial glutathione transporter SLC25A40

1

0

High-throughput

0.279

Low

358558

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.279

Low

358568

FOXD3
Forkhead box protein D3

1

0

High-throughput

0.279

Low

358575

YIPF1
Protein YIPF1

1

0

High-throughput

0.279

Low

207406

LAT
Linker for activation of T-cells family member 1

1

0

High-throughput

0.269

Low

358565

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

0

High-throughput

0.269

Low

358516

MF13A
Transmembrane protein 180

1

0

High-throughput

0.249

Low

358559

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

320940

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024