HitPredict

Interactor 1: UB2J2 (Q8N2K1)
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)
Gene: UBE2J2

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 259 Hs			1 1024
+	Hs
		919895 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		125575 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1231676 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		1231677 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		1176340 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		919710 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		919860 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125808 UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125262 UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125335 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1294888 UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808078 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		919827 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		919834 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		919762 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		919889 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HECW2_HUMAN (534-1024): 2.54e-153: 496: 23.43
+	Hs
		919867 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Hs
		919869 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Hs
		1125821 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		HERC4_HUMAN (317-431): 2.55e-13: 76.6: 11.02
+	Hs
		919741 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HERC4_HUMAN (317-431): 2.55e-13: 76.6: 11.02