HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31753913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 801
+	Hs
		123251 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		123146 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		631418 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00
+	Hs
		631371 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00
+	Hs
		244836 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		1067203 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		1027010 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		243752 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		800386 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		244377 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		244073 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Mm
		1266178 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		TRI66_MOUSE (2-527): 4.31e-57: 214: 17.88
+	Hs
		1262805 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		PHIP_HUMAN (76-730): 1.12e-13: 77.6: 11.21
+	Mm
		1143042 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		TRI66_MOUSE (2-527): 4.31e-57: 214: 17.88
+	Hs
		998641 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Hs
		800357 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Hs
		319183 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD1_HUMAN (54-330): 3.85e-29: 127: 17.79
+	Hs
		1027324 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRPF3_HUMAN (8-510): 5.66e-28: 123: 15.88
+	Hs
		316175 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		BRWD1_HUMAN (43-216): 8.56e-10: 64.9: 16.38
+	Hs
		1027151 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		PHIP_HUMAN (76-730): 1.12e-13: 77.6: 11.21