HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	26496610, 18927235, 36089195
Identification Methods	affinity chromatography technology, protein complementation assay, proximity labelling technology, bimolecular fluorescence complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 136
+	Hs
		123231 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		123254 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		123269 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		111555 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		K7EK07_HUMAN (1-132): 7.81e-58: 177: 100.00
+	Mm
		223226 CBX4_MOUSE (1-560): 5.82e-156: 459: 88.43		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Mm
		675496 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		935156 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952579 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		934768 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952341 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1059154 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1059165 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		952770 CBX6_MOUSE (1-419): 2.28e-79: 257: 24.14		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		828230 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		316000 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		316012 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		316040 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		316070 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		316055 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		935387 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		H31_HUMAN (1-136): 3.08e-60: 183: 96.32