Protein: PDLI5
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)

Gene: PDLI5, PDLIM5
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q96HC4

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0005080 - protein kinase C binding
GO:0005829 - cytosol
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1156179

ZYX
Zyxin

2

20

High-throughput

0.815

High

1393046

PDLI7
PDZ and LIM domain protein 7

2

17

High-throughput

0.811

High

1036540

ID2
DNA-binding protein inhibitor ID-2

1

2

Small-scale

0.756

High

249185

DSCAM
Cell adhesion molecule DSCAM

1

6

High-throughput

0.698

High

389475

FINC
Fibronectin

1

5

High-throughput

0.691

High

1104459

ILK
Scaffold protein ILK

1

19

High-throughput

0.691

High

832324

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.647

High

1037113

ID3
DNA-binding protein inhibitor ID-3

1

2

Small-scale

0.647

High

242579

PRKN
E3 ubiquitin-protein ligase parkin

3

10

High-throughput

0.640

High

862374

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.640

High

537705

HSP7C
Heat shock cognate 71 kDa protein

3

4

High-throughput

0.624

High

186573

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

Small-scale

0.618

High

976483

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.618

High

1295532

MIB1
E3 ubiquitin-protein ligase MIB1

1

8

Small-scale

0.618

High

1393027

PDLI5
PDZ and LIM domain protein 5

1

17

High-throughput

0.618

High

1393052

ZO2
Tight junction protein 2

1

9

High-throughput

0.618

High

1393054

TES
Testin

1

16

High-throughput

0.618

High

1393035

SYT11
Synaptotagmin-11

2

1

High-throughput

0.611

High

800044

COIL
Coilin

2

0

High-throughput

0.601

High

1055670

GABP1
GA-binding protein subunit beta-1

1

7

High-throughput

0.594

High

1108042

SQSTM
Sequestosome-1

2

14

High-throughput

0.584

High

1115905

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

13

High-throughput

0.584

High

967912

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.575

High

279457

TULP3
Tubby-related protein 3

2

1

High-throughput

0.574

High

1213579

PHF19
PHD finger protein 19

2

1

High-throughput

0.574

High

1335539

NF2IP
NFATC2-interacting protein

2

1

High-throughput

0.574

High

1393062

EMIL1
EMILIN-1

2

5

High-throughput

0.574

High

1393028

CC136
Coiled-coil domain-containing protein 136

2

10

High-throughput

0.573

High

950370

KR107
Keratin-associated protein 10-7

1

5

High-throughput

0.573

High

1230198

K1C40
Keratin, type I cytoskeletal 40

1

7

High-throughput

0.573

High

564209

CFTR
Cystic fibrosis transmembrane conductance regulator

2

5

High-throughput

0.571

High

1327780

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.571

High

412432

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.553

High

945068

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.553

High

1255060

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

436715

KPCB
Protein kinase C beta type

1

16

Small-scale

0.552

High

1393041

TRI39
E3 ubiquitin-protein ligase TRIM39

1

6

High-throughput

0.541

High

347250

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

1252932

BAKOR
Beclin 1-associated autophagy-related key regulator

1

2

High-throughput

0.536

High

1254270

UBR3
E3 ubiquitin-protein ligase UBR3

1

1

High-throughput

0.536

High

1347835

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.536

High

799392

BRCA1
Breast cancer type 1 susceptibility protein

2

11

High-throughput

0.533

High

156071

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.515

High

464199

TPM2
Tropomyosin beta chain

1

12

High-throughput

0.515

High

931060

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.515

High

570560

GFAP
Glial fibrillary acidic protein

1

15

High-throughput

0.515

High

843866

HD
Huntingtin

1

3

High-throughput

0.515

High

927485

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

295862

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.513

High

569455

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

0

High-throughput

0.513

High

884686

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1310311

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1360720

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

1393050

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.493

High

69815

ZN785
Zinc finger protein 785

1

2

High-throughput

0.489

High

608332

EGLN
Endoglin

1

3

High-throughput

0.489

High

692778

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

1239087

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

1

3

High-throughput

0.489

High

1384101

ARRD3
Arrestin domain-containing protein 3

1

1

High-throughput

0.489

High

1393057

AT7L1
Ataxin-7-like protein 1

1

4

High-throughput

0.489

High

1035014

KPCE
Protein kinase C epsilon type

1

16

Small-scale

0.481

High

1393040

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.481

High

173224

XPO1
Exportin-1

1

15

High-throughput

0.479

High

315883

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

346191

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

401296

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

13

High-throughput

0.479

High

459717

PROF1
Profilin-1

1

2

Small-scale

0.479

High

474898

VIME
Vimentin

1

15

High-throughput

0.479

High

508439

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

521409

ARAF
Serine/threonine-protein kinase A-Raf

1

11

High-throughput

0.479

High

556281

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

643026

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

651402

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.479

High

764963

CTNB1
Catenin beta-1

1

6

High-throughput

0.479

High

765793

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.479

High

831240

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

920195

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.479

High

941039

HDAC4
Histone deacetylase 4

1

5

High-throughput

0.479

High

953034

ACTB
Actin, cytoplasmic 1

1

13

High-throughput

0.479

High

970922

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1014580

SMAD3
Mothers against decapentaplegic homolog 3

1

7

Small-scale

0.479

High

1094610

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.479

High

1095437

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.479

High

1100960

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

1113990

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1125187

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

11

Small-scale

0.479

High

1226497

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.479

High

1260293

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

Small-scale

0.479

High

1288559

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

Small-scale

0.479

High

1289534

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1350410

BICD2
Protein bicaudal D homolog 2

1

17

High-throughput

0.479

High

1350940

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

Small-scale

0.479

High

1363820

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1364206

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.479

High

1364517

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1370291

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1380624

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1391157

BICD1
Protein bicaudal D homolog 1

1

18

High-throughput

0.479

High

1393031

RANB9
Ran-binding protein 9

1

3

High-throughput

0.479

High

1393033

NECD
Necdin

1

4

High-throughput

0.479

High

1393034

TRI56
E3 ubiquitin-protein ligase TRIM56

1

19

Small-scale

0.479

High

1393037

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1393038

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

7

Small-scale

0.479

High

1393043

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

1393045

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

5

Small-scale

0.479

High

1393051

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

1393053

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1393056

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1393059

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

1393060

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

1393061

ADIP
Afadin- and alpha-actinin-binding protein

1

2

High-throughput

0.479

High

1137456

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.470

High

1217753

GFI1B
Zinc finger protein Gfi-1b

1

2

High-throughput

0.464

High

1393029

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1393042

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

142022

FCN1
Ficolin-1

1

2

Small-scale

0.457

High

1393047

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

273915

CNOT3
CCR4-NOT transcription complex subunit 3

1

6

High-throughput

0.445

High

1309396

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

2

High-throughput

0.445

High

589411

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

696211

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

1028116

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

1

Small-scale

0.437

High

1245116

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.437

High

1256558

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

1276638

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1310625

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

3

High-throughput

0.437

High

1332694

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.437

High

1352340

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.437

High

1367014

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1393030

CIC
Protein capicua homolog

1

7

High-throughput

0.437

High

1393032

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.437

High

1393036

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.437

High

1393039

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.437

High

1393049

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

6

High-throughput

0.437

High

1393055

XPO7
Exportin-7

1

14

High-throughput

0.437

High

1393058

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.437

High

1237983

Q6NSK7
RIN3 protein

1

14

High-throughput

0.417

High

1102

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

379472

IGHG4
Immunoglobulin heavy constant gamma 4

1

3

High-throughput

0.407

High

1393044

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.407

High

943683

RWD2B
RWD domain-containing protein 2B

3

0

High-throughput

0.347

High

1349516

METL6
tRNA N(3)-cytidine methyltransferase METTL6

3

0

High-throughput

0.347

High

220707

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

505107

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

1387305

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

1042608

TFF2
Trefoil factor 2

1

0

High-throughput

0.268

Low

84340

B6ZDN3
Doublecortin domain containing 1

1

0

High-throughput

0.249

Low

377686

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1327133

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1329810

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.249

Low

1104058

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1393048

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025