Protein: P5CR2
Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)

Gene: P5CR2, PYCR2
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q96C36

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006561 - proline biosynthetic process
GO:0034599 - cellular response to oxidative stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687258

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

4

14

High-throughput

0.895

High

1121421

P5CR3
Pyrroline-5-carboxylate reductase 3

3

14

High-throughput

0.861

High

1286327

P5CR2
Pyrroline-5-carboxylate reductase 2

1

14

High-throughput

0.618

High

440656

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

1

High-throughput

0.611

High

1051030

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

1068036

PDK1
[Pyruvate dehydrogenase

2

4

High-throughput

0.611

High

1218885

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

2

High-throughput

0.611

High

1217492

AHNK2
Protein AHNAK2

3

1

High-throughput

0.609

High

1286383

NUDT5
ADP-sugar pyrophosphatase

3

1

High-throughput

0.609

High

262906

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

499995

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.584

High

525587

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

1

High-throughput

0.584

High

1017987

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

1086706

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1022964

CDC16
Cell division cycle protein 16 homolog

2

4

High-throughput

0.574

High

1286379

CDC23
Cell division cycle protein 23 homolog

2

4

High-throughput

0.574

High

666153

SHC1
SHC-transforming protein 1

2

2

High-throughput

0.571

High

1062253

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

7

Small-scale

0.571

High

305016

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.558

High

1135955

CE162
Centrosomal protein of 162 kDa

2

3

High-throughput

0.537

High

1085241

PDK4
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

925508

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

High-throughput

0.521

High

1173138

SYDE1
Rho GTPase-activating protein SYDE1

2

3

High-throughput

0.521

High

1234544

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.521

High

398388

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

452850

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

739222

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

882965

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.513

High

843835

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.494

High

844184

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.494

High

121521

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.489

High

506639

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.489

High

581822

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.489

High

672872

CDC27
Cell division cycle protein 27 homolog

1

4

High-throughput

0.489

High

682927

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

4

High-throughput

0.489

High

999643

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.489

High

1030407

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.489

High

1042237

CUL3
Cullin-3

1

2

High-throughput

0.489

High

1147697

TENS3
Tensin-3

1

1

High-throughput

0.489

High

1286330

APC16
Anaphase-promoting complex subunit 16

1

1

High-throughput

0.489

High

1286335

AURKB
Aurora kinase B

1

1

High-throughput

0.489

High

1286351

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.489

High

1286354

5NT3A
Cytosolic 5'-nucleotidase 3A

1

1

High-throughput

0.489

High

1286380

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.489

High

1286381

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.489

High

59251

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

63412

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

204016

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

264984

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

270087

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

276861

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

325310

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

327510

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

336887

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

377576

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

486598

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

737435

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

751752

GRP75
Stress-70 protein, mitochondrial

1

3

High-throughput

0.479

High

777668

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

789911

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

799309

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

803180

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

827516

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

958991

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

981358

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

990221

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1014445

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1020511

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1045817

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1074626

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1128202

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1152922

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1157951

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

1183974

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1185331

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

1242972

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

1269323

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1281300

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1282249

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

5

High-throughput

0.479

High

1282778

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

1284501

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

1285724

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1286328

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

1286329

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

2

High-throughput

0.479

High

1286331

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1286332

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1286334

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1286336

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

1286338

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

1286340

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1286342

EFGM
Elongation factor G, mitochondrial

1

5

High-throughput

0.479

High

1286345

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

1286348

TR61B
tRNA

1

1

High-throughput

0.479

High

1286349

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1286350

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1286352

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1286353

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

1286356

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1286357

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1286358

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

1286359

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1286361

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1286362

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1286363

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1286367

NGRN
Neugrin

1

1

High-throughput

0.479

High

1286368

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

1286369

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1286370

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1286371

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

1286372

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

1286374

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

1286375

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1286376

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

1286385

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

1286341

CIC
Protein capicua homolog

1

2

High-throughput

0.464

High

1183186

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1286333

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1286347

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1101

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

1286387

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

173074

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

282708

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.437

High

295104

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

347540

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

385320

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

609465

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

666633

LTK
Leukocyte tyrosine kinase receptor

1

4

High-throughput

0.437

High

684945

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.437

High

798970

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

951220

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

969911

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

994508

QOR
Quinone oxidoreductase

1

1

High-throughput

0.437

High

998964

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.437

High

1029716

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1035962

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1049111

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.437

High

1056928

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.437

High

1080217

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

1136219

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

1158833

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.437

High

1171155

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1188690

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1201585

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

1219436

LMTK2
Serine/threonine-protein kinase LMTK2

1

4

High-throughput

0.437

High

1222508

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.437

High

1224226

DOCK3
Dedicator of cytokinesis protein 3

1

2

High-throughput

0.437

High

1245121

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

1267075

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.437

High

1286337

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.437

High

1286339

LMTK3
Serine/threonine-protein kinase LMTK3

1

5

High-throughput

0.437

High

1286343

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.437

High

1286344

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.437

High

1286346

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.437

High

1286360

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1286364

RC3H2
Roquin-2

1

4

Small-scale

0.437

High

1286366

DNJC4
DnaJ homolog subfamily C member 4

1

5

High-throughput

0.437

High

1286377

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1286378

FKBPL
FK506-binding protein-like

1

3

High-throughput

0.437

High

1286382

KCND3
Potassium voltage-gated channel subfamily D member 3

1

1

Small-scale

0.437

High

1286386

DJC15
DnaJ homolog subfamily C member 15

1

2

High-throughput

0.437

High

1220375

SKA3
Spindle and kinetochore-associated protein 3

3

0

High-throughput

0.347

High

1268066

MY18A
Unconventional myosin-XVIIIa

3

0

High-throughput

0.347

High

1285419

SKA1
Spindle and kinetochore-associated protein 1

3

0

High-throughput

0.347

High

117909

MYO1F
Unconventional myosin-If

2

0

High-throughput

0.318

High

875205

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.318

High

305188

UBE4B
Ubiquitin conjugation factor E4 B

1

0

Small-scale

0.292

High

245389

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

451526

CLCA
Clathrin light chain A

1

0

High-throughput

0.279

Low

536545

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.279

Low

564992

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.279

Low

586907

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

942017

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.279

Low

1078130

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.279

Low

1087327

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.279

Low

1233014

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1286355

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.279

Low

521386

SKIL
Ski-like protein

1

0

High-throughput

0.265

Low

395434

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

134158

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.249

Low

302689

ARHGF
Rho guanine nucleotide exchange factor 15

1

0

High-throughput

0.249

Low

338820

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

617623

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.249

Low

665511

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

719577

MERL
Merlin

1

0

High-throughput

0.249

Low

779884

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

978846

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1018631

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.249

Low

1074965

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1251698

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.249

Low

1286365

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

1286373

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

575816

VINC
Vinculin

1

0

High-throughput

0.232

Low

1134743

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1286384

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024