HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: SCML1 (Q9UN30)
Sex comb on midleg-like protein 1
Gene: SCML1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	27705803
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 329
+	Hs
		123346 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		SCML2_HUMAN (109-325): 7.08e-47: 170: 31.44
+	Hs
		123303 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		SCMH1_HUMAN (131-325): 1.54e-46: 168: 30.85
+	Hs
		1059202 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCML1_HUMAN (1-329): 1.77e-123: 359: 100.00
+	Hs
		123234 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC1_HUMAN (189-324): 4.41e-34: 134: 26.47
+	Hs
		123280 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC2_HUMAN (146-324): 1.16e-33: 133: 19.23
+	Hs
		123290 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC3_HUMAN (162-324): 7.6e-33: 130: 21.47
+	Hs
		316200 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		SCML1_HUMAN (1-329): 1.77e-123: 359: 100.00
+	Dr
		1193375 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		PHC2_DANRE (146-324): 4.31e-38: 145: 24.34
+	Hs
		1059204 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCML2_HUMAN (109-325): 7.08e-47: 170: 31.44
+	Hs
		1059182 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCMH1_HUMAN (131-325): 1.54e-46: 168: 30.85
+	Mm
		675498 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PHC1_MOUSE (189-324): 1.76e-33: 132: 27.21
+	Mm
		675500 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PHC3_MOUSE (162-324): 2.01e-33: 132: 21.47
+	Hs
		943062 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC1_HUMAN (189-324): 4.41e-34: 134: 26.47
+	Hs
		1059170 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC2_HUMAN (146-324): 1.16e-33: 133: 19.23
+	Hs
		1059177 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC3_HUMAN (162-324): 7.6e-33: 130: 21.47
+	Hs
		1059207 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		LMBL1_HUMAN (156-306): 8.18e-27: 113: 12.65
+	Hs
		316124 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		SCMH1_HUMAN (131-325): 1.54e-46: 168: 30.85
+	Hs
		316005 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC1_HUMAN (189-324): 4.41e-34: 134: 26.47
+	Hs
		316088 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC2_HUMAN (146-324): 1.16e-33: 133: 19.23
+	Hs
		316103 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC3_HUMAN (162-324): 7.6e-33: 130: 21.47